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A narrative overview of utilizing biomaterials to recapitulate the salient regenerative features of dental-derived mesenchymal stem cells
International Journal of Oral Science ( IF 14.9 ) Pub Date : 2021-06-30 , DOI: 10.1038/s41368-021-00126-4
Sevda Pouraghaei Sevari 1 , Sahar Ansari 1 , Alireza Moshaverinia 1, 2
Affiliation  

Tissue engineering approaches have emerged recently to circumvent many limitations associated with current clinical practices. This elegant approach utilizes a natural/synthetic biomaterial with optimized physiomechanical properties to serve as a vehicle for delivery of exogenous stem cells and bioactive factors or induce local recruitment of endogenous cells for in situ tissue regeneration. Inspired by the natural microenvironment, biomaterials could act as a biomimetic three-dimensional (3D) structure to help the cells establish their natural interactions. Such a strategy should not only employ a biocompatible biomaterial to induce new tissue formation but also benefit from an easily accessible and abundant source of stem cells with potent tissue regenerative potential. The human teeth and oral cavity harbor various populations of mesenchymal stem cells (MSCs) with self-renewing and multilineage differentiation capabilities. In the current review article, we seek to highlight recent progress and future opportunities in dental MSC-mediated therapeutic strategies for tissue regeneration using two possible approaches, cell transplantation and cell homing. Altogether, this paper develops a general picture of current innovative strategies to employ dental-derived MSCs combined with biomaterials and bioactive factors for regenerating the lost or defective tissues and offers information regarding the available scientific data and possible applications.



中文翻译:

利用生物材料概括牙源性间充质干细胞显着再生特征的叙述性概述

最近出现的组织工程方法可以规避与当前临床实践相关的许多限制。这种优雅的方法利用具有优化的物理力学特性的天然/合成生物材料作为传递外源干细胞和生物活性因子的载体,或诱导内源细胞的局部募集以进行原位组织再生。受自然微环境的启发,生物材料可以充当仿生三维 (3D) 结构,帮助细胞建立自然相互作用。这种策略不仅应采用生物相容性生物材料来诱导新组织形成,而且还应受益于易于获取且丰富的具有强大组织再生潜力的干细胞来源。人类牙齿和口腔中含有各种具有自我更新和多谱系分化能力的间充质干细胞(MSC)群。在当前的综述文章中,我们试图重点介绍牙科 MSC 介导的组织再生治疗策略的最新进展和未来机遇,使用细胞移植和细胞归巢两种可能的方法。总而言之,本文概述了当前利用牙源性间充质干细胞与生物材料和生物活性因子相结合来再生丢失或有缺陷的组织的创新策略,并提供了有关可用科学数据和可能应用的信息。

更新日期:2021-06-30
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