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The role of hippocampal mossy cells in novelty detection
Neurobiology of Learning and Memory ( IF 2.7 ) Pub Date : 2021-06-30 , DOI: 10.1016/j.nlm.2021.107486
Felipe Fredes 1 , Ryuichi Shigemoto 2
Affiliation  

At the encounter with a novel environment, contextual memory formation is greatly enhanced, accompanied with increased arousal and active exploration. Although this phenomenon has been widely observed in animal and human daily life, how the novelty in the environment is detected and contributes to contextual memory formation has lately started to be unveiled. The hippocampus has been studied for many decades for its largely known roles in encoding spatial memory, and a growing body of evidence indicates a differential involvement of dorsal and ventral hippocampal divisions in novelty detection. In this brief review article, we discuss the recent findings of the role of mossy cells in the ventral hippocampal moiety in novelty detection and put them in perspective with other novelty-related pathways in the hippocampus. We propose a mechanism for novelty-driven memory acquisition in the dentate gyrus by the direct projection of ventral mossy cells to dorsal dentate granule cells. By this projection, the ventral hippocampus sends novelty signals to the dorsal hippocampus, opening a gate for memory encoding in dentate granule cells based on information coming from the entorhinal cortex. We conclude that, contrary to the presently accepted functional independence, the dorsal and ventral hippocampi cooperate to link the novelty and contextual information, and this dorso-ventral interaction is crucial for the novelty-dependent memory formation.



中文翻译:

海马苔藓细胞在新奇检测中的作用

在遇到新环境时,情境记忆的形成大大增强,伴随着唤醒和积极探索的增加。尽管这种现象已在动物和人类日常生活中广泛观察到,但最近才开始揭示环境中的新奇事物是如何被检测到并有助于形成上下文记忆的。海马体已经被研究了几十年,因为它在编码空间记忆中的作用众所周知,越来越多的证据表明,海马背侧和腹侧的分裂在新奇检测中的参与程度不同。在这篇简短的评论文章中,我们讨论了苔藓细胞在海马腹侧部分在新奇检测中的作用的最新发现,并将它们与海马中其他与新奇相关的途径相结合。我们提出了一种通过将腹侧苔藓细胞直接投射到背侧齿状颗粒细胞来在齿状回中获得新奇驱动记忆的机制。通过这种投射,腹侧海马体向背侧海马体发送新奇信号,根据来自内嗅皮层的信息,为齿状颗粒细胞中的记忆编码打开了一扇门。我们得出结论,与目前公认的功能独立性相反,背侧和腹侧海马体合作将新奇信息和上下文信息联系起来,这种背腹相互作用对于新奇依赖的记忆形成至关重要。根据来自内嗅皮层的信息,为齿状颗粒细胞中的记忆编码打开了一扇门。我们得出结论,与目前公认的功能独立性相反,背侧和腹侧海马体合作将新奇信息和上下文信息联系起来,这种背腹相互作用对于新奇依赖的记忆形成至关重要。根据来自内嗅皮层的信息,为齿状颗粒细胞中的记忆编码打开了一扇门。我们得出结论,与目前公认的功能独立性相反,背侧和腹侧海马体合作将新奇信息和上下文信息联系起来,这种背腹相互作用对于新奇依赖的记忆形成至关重要。

更新日期:2021-07-06
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