Abstract

In recent years, nanotechnology has been widely used in modern biomedicine. Nano-delivered drugs have great advantages that other platforms do not have in terms of human drug energy release, in vivo drug retention, physicochemical stability, and human surface physical engineering properties. Therefore, it is necessary to actively carry out research on the preparation of phenylalanine-based polyesteramide Nano-delivery system and its anti-prostate cancer treatment in vitro. The purpose of this article is to investigate the preparation of a polyesteramide nano-drug delivery system based on p-phenylalanine and its related research in vitro for prostate cancer. (PSMA +), divided them into control group, DOX @ 8p6 group, DOX group, and compared the anti-prostate cancer effect of each group. The results showed that after 24 h incubation, the cell survival rate in the control group decreased from 100% to 97.68%, and the apoptosis rate was 2.32%, while the cell survival rate in the DOX group decreased from 100% to 70.84%, and the apoptosis rate was 29.16. %; The survival rate of DOX @ 8p6 cells decreased from 100% to 38.38%, and the apoptosis rate was 61.62%. It can be seen that the polyesteramide Nano-delivery system of phenylalanine has a good effect on anti-prostate cancer.

摘要

近年来，纳米技术在现代生物医学中得到了广泛的应用。纳米药物在人体药物能量释放、体内药物滞留、理化稳定性、人体表面物理工程特性等方面具有其他平台所不具备的巨大优势。因此，有必要积极开展苯丙氨酸基聚酯酰胺纳米给药系统的制备及其体外抗前列腺癌治疗的研究。本文旨在探讨基于对苯丙氨酸的聚酯酰胺纳米递药系统的制备及其体外治疗前列腺癌的相关研究。(PSMA+)，将其分为对照组、DOX@8p6组、DOX组，并比较各组的抗前列腺癌效果。结果表明，培养 24 h 后，对照组细胞存活率从100%下降到97.68%，凋亡率为2.32%，而DOX组细胞生存率从100%下降到70.84%，凋亡率为29.16。%; DOX@8p6细胞存活率从100%下降到38.38%，凋亡率为61.62%。可见苯丙氨酸的聚酯酰胺纳米递送系统对抗前列腺癌有很好的效果。