A synergistic Pd/Cu catalyzed enantioselective decarboxylative allylation of vinylethylene carbonates with glycine iminoesters has been developed. This protocol exhibit excellent functional group tolerance to deliver valuable trisubstituted allylic amino acid derivatives in high yields, exclusive regioselectivities and excellent stereoselectivities. Signifi cantly, this method was proven to be suffi cient in the gram scale synthesis of chiral trisubstituted allylic amino acid while retaining the enantioselectivity and geometric control.

中文翻译：

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用于乙烯基碳酸亚乙酯与甘氨酸亚氨基酯立体选择性烯丙基化的协同 Pd/Cu 催化：对映选择性获得不同的三取代烯丙基氨基酸衍生物

已经开发了一种协同 Pd/Cu 催化的乙烯基碳酸亚乙酯与甘氨酸亚氨基酯的对映选择性脱羧烯丙基化反应。该方案表现出出色的官能团耐受性，以高产率、独特的区域选择性和出色的立体选择性提供有价值的三取代烯丙基氨基酸衍生物。值得注意的是，该方法被证明足以在克级合成手性三取代烯丙基氨基酸，同时保留对映选择性和几何控制。