Intracranial electroencephalographic (iEEG) recordings from patients with epilepsy provide distinct opportunities and novel data for the study of co-occurring psychiatric disorders. Comorbid psychiatric disorders are very common in drug resistant epilepsy and their added complexity warrants careful consideration. In this review, we first discuss psychiatric comorbidities and symptoms in patients with epilepsy. We describe how epilepsy can potentially impact patient presentation and how these factors can be addressed in the experimental designs of studies focused on the electrophysiologic correlates of mood. Second, we review emerging technologies to integrate long-term iEEG recording with dense behavioral tracking in naturalistic environments. Third, we explore questions on how best to address the intersection between epilepsy and psychiatric comorbidities. Advances in ambulatory iEEG and long-term behavioral monitoring technologies will be instrumental for studying the intersection of seizures, epilepsy, psychiatric comorbidities, and their underlying circuitry.

中文翻译：

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用于癫痫患者合并精神疾病的电路发现和研究的侵入性电生理学：挑战、机遇和新技术

癫痫患者的颅内脑电图 (iEEG) 记录为研究同时发生的精神疾病提供了独特的机会和新的数据。共病精神疾病在耐药性癫痫中非常常见，它们增加的复杂性值得仔细考虑。在这篇综述中，我们首先讨论癫痫患者的精神合并症和症状。我们描述了癫痫如何潜在地影响患者的表现，以及如何在侧重于情绪电生理相关性的研究的实验设计中解决这些因素。其次，我们回顾了新兴技术，以将长期 iEEG 记录与自然环境中的密集行为跟踪相结合。第三，我们探讨了如何最好地解决癫痫和精神疾病之间的交叉问题。动态 iEEG 和长期行为监测技术的进步将有助于研究癫痫发作、癫痫、精神病合并症及其潜在电路的交叉点。