In the 40 years since vasopressin (AVP) was reported to have a central action with respect to raising blood pressure, the finding has been repeatedly replicated using a variety of complimentary approaches. The role of AVP as a central neurotransmitter involved in control of the cardiovascular system is now textbook material. However, it is evident that brain AVP plays, at best, a minor role in regulation of normal blood pressure. However, it appears to be an important player in a several cardiovascular-associated pathologies, ranging from hypertension to neural changes associated with heart failure. There are many interventions that have been shown to affect neural function, many of which are associated with alterations in behaviour. Possible alterations in neuronal AVP actions relevant to cardiovascular control in the setting of chronic inflammatory disease, early-life stress and inflammation are suggested areas for future research.

中文翻译：

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血管加压素和心血管系统的中枢控制：40 年回顾

自血管加压素 (AVP) 被报道在升高血压方面具有核心作用以来的 40 年中，这一发现已被使用各种互补的方法反复复制。AVP 作为参与控制心血管系统的中枢神经递质的作用现在是教科书材料。然而，很明显，脑 AVP 充其量在调节正常血压中起次要作用。然而，它似乎是几种心血管相关疾病的重要参与者，从高血压到与心力衰竭相关的神经变化。有许多干预措施已被证明会影响神经功能，其中许多与行为改变有关。