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Structure of an H3N2 influenza virus nucleoprotein
Acta Crystallographica Section F ( IF 1.072 ) Pub Date : 2021-06-29 , DOI: 10.1107/s2053230x2100635x
Michael L Knight 1 , Haitian Fan 1 , David L V Bauer 2 , Jonathan M Grimes 3 , Ervin Fodor 1 , Jeremy R Keown 3
Affiliation  

Influenza A viruses of the H1N1 and H3N2 subtypes are responsible for seasonal epidemic events. The influenza nucleoprotein (NP) binds to the viral genomic RNA and is essential for its replication. Efforts are under way to produce therapeutics and vaccines targeting the NP. Despite this, no structure of an NP from an H3N2 virus has previously been determined. Here, the structure of the A/Northern Territory/60/1968 (H3N2) influenza virus NP is presented at 2.2 Å resolution. The structure is highly similar to those of the A/WSN/1933 (H1N1) and A/Hong Kong/483/97 (H5N1) NPs. Nonconserved amino acids are widely dispersed both at the sequence and structural levels. A movement of the 73–90 RNA-binding loop is observed to be the key difference between the structure determined here and previous structures. The data presented here increase the understanding of structural conservation amongst influenza NPs and may aid in the design of universal interventions against influenza.

中文翻译:

H3N2 流感病毒核蛋白的结构

H1N1 和 H3N2 亚型甲型流感病毒是造成季节性流行病的原因。流感核蛋白 (NP) 与病毒基因组 RNA 结合,对其复制至关重要。目前正在努力生产针对 NP 的治疗方法和疫苗。尽管如此,之前尚未确定 H3N2 病毒的 NP 结构。此处以 2.2 Å 分辨率展示了 A/北领地/60/1968 (H3N2) 流感病毒 NP 的结构。该结构与 A/WSN/1933 (H1N1) 和 A/Hong Kong/483/97 (H5N1) NP 的结构高度相似。非保守氨基酸在序列和结构水平上广泛分散。观察到 73-90 RNA 结合环的运动是此处确定的结构与先前结构之间的主要区别。这里提供的数据增加了对流感纳米颗粒结构保护的理解,并可能有助于设计针对流感的通用干预措施。
更新日期:2021-07-01
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