To examine the association between psychological resilience and cognitive function and investigate the role of acute inflammation as an effect modifier. Total 7535 people from the Cardiovascular and Metabolic Disease Etiology Research Center (CMERC), aged ≥ 50 years and residing in areas near Seoul, South Korea, were included in this cross-sectional analysis. Stressful life events in the past 6 months were gauged by the Life Experience Survey, and current depression symptoms were analyzed with the Beck Depression Inventory-II. Participants were categorized into the following four groups according to their past experience and depression status: reference, resilient, reactive depression, and vulnerable depression. Cognitive function was evaluated using the mini-mental state examination (MMSE). The level of high-sensitivity C-reactive protein (hsCRP) was measured from blood samples. A generalized linear model was used. Upon adjusting for socio-demographic factors, comorbidity, and lifestyle factors, the final model was stratified with the highest quartile of the hsCRP level by sex. Compared to the reference group, the resilient group showed higher MMSE, which was also significant in women (adj-β = 0.280, p-value < 0.001). Vulnerable depression group showed a significantly lower MMSE (adj-β = − -0.997, p-value 0.002), especially in men. This pattern seemed to be limited to the low hsCRP subgroup. We provided evidence from the largest Korean population used to evaluate the association between psychological resilience and cognition, which was more prominent in low inflammatory status. Psychological resilience was associated with a lower likelihood of cognitive deficit in women. This pattern was modulated by inflammatory status.

检查心理弹性和认知功能之间的关联，并研究急性炎症作为效果调节剂的作用。该横断面分析包括来自心血管和代谢疾病病因研究中心 (CMERC) 的 7535 名年龄≥50 岁且居住在韩国首尔附近地区的人。过去 6 个月的压力生活事件通过生活体验调查来衡量，当前的抑郁症状通过贝克抑郁量表-II 进行分析。参与者根据他们过去的经历和抑郁状态分为以下四组：参考、弹性、反应性抑郁和易感抑郁。认知功能评估使用简易精神状态检查（MMSE）。从血液样本中测量高敏 C 反应蛋白 (hsCRP) 的水平。使用广义线性模型。在调整社会人口因素、合并症和生活方式因素后，最终模型按性别按 hsCRP 水平的最高四分位数分层。与参考组相比，弹性组表现出更高的 MMSE，这在女性中也很显着（adj-β  = 0.280，p值 < 0.001）。易感抑郁组的 MMSE 显着降低（adj- β  = - -0.997，p值 0.002），尤其是在男性中。这种模式似乎仅限于低 hsCRP 亚组。我们提供了来自最大的韩国人口的证据，用于评估心理弹性与认知之间的关联，这在低炎症状态下更为突出。心理弹性与女性认知缺陷的可能性较低有关。这种模式受炎症状态的调节。