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Clonal distribution, antimicrobial resistance, and pilus islets in S.pneumoniae isolates recovered from PCV10-vaccinated children with suppurative AOM in Bulgaria (2015-2020), BULGARIA
Japanese Journal of Infectious Diseases ( IF 2.2 ) Pub Date : 2021-06-30 , DOI: 10.7883/yoken.jjid.2021.106
Alexandra Sashova Alexandrova 1 , Daniela Rosenova Pencheva 2 , Ivan Gergov Mitov 1 , Lena Petrova Setchanova 1
Affiliation  

Streptococcus pneumoniae is still a leading bacterial pathogen of acute otitis media (AOM), despite the available pneumococcal conjugate vaccines (PCVs). We conducted a study on the population structure, antibiotic nonsusceptibility, serotype distribution, and presence of pilus in middle ear fluids - S. pneumoniae isolates recovered from PCV10-vaccinated children with suppurative АОМ in Bulgaria. Non-susceptibility was revealed in 68.75% (n=33) of the isolates. Multidrug-resistance (MDR) has been detected in 60.4%. The dual macrolide resistance mechanism was predominant. Most widespread were non-PCV10 serotypes 3 (27.1%, n=13), 19A (25.0%, n=12), and VT 19F (23.0%, n=11). A total of 64.6% were non-PCV10-serotypes. Presence of Pilus type I was observed mostly in PCV10-serotypes. We disclosed a strong association between CCs, serotype, and antimicrobial resistance. The MLST revealed the presence of four CCs: CC320 (39.6%), CC505 (12.5%), CC1377 8.3%), and CC230 (8.3%), respectively. The most abundant CC320 comprised MDR 19A and 19F isolates. CC230 clustered MDR isolates from serotype 19A, 6C, and 14. CC505 and CC1377 covered serotype 3 susceptible isolates. The vaccine-induced changes and trends in antimicrobial resistance and clonality must be an object of systematic investigations.



中文翻译:

保加利亚(2015-2020 年)从接种 PCV10 的化脓性 AOM 儿童中回收的肺炎链球菌分离株中的克隆分布、抗菌素耐药性和菌毛胰岛(2015-2020 年),保加利亚

尽管有可用的肺炎球菌结合疫苗 (PCV),但肺炎链球菌仍然是急性中耳炎 (AOM) 的主要细菌病原体。我们对人群结构、抗生素不敏感性、血清型分布和中耳液中菌毛的存在进行了一项研究 -肺炎链球菌从保加利亚接种过 PCV10 的化脓性 АОМ 的儿童中分离出分离株。68.75% (n=33) 的分离株显示不敏感。已在 60.4% 中检测到多重耐药性 (MDR)。双大环内酯类耐药机制占主导地位。最普遍的是非 PCV10 血清型 3(27.1%,n=13)、19A(25.0%,n=12)和 VT 19F(23.0%,n=11)。共有 64.6% 为非 PCV10 血清型。主要在 PCV10 血清型中观察到存在 I 型菌毛。我们揭示了 CC、血清型和抗菌素耐药性之间的强关联。MLST 显示存在四种 CC:CC320 (39.6%)、CC505 (12.5%)、CC1377 (8.3%) 和 CC230 (8.3%)。最丰富的 CC320 包括 MDR 19A 和 19F 分离株。CC230 来自血清型 19A、6C 和 14 的 MDR 簇状分离株。CC505 和 CC1377 涵盖了血清型 3 敏感分离株。

更新日期:2021-06-29
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