OBJECTIVE Vasomotor symptoms affect 60-80% of women during the menopausal transition. Anxiety, depression, and anxiety sensitivity can have an important role in the distressful experience of vasomotor symptoms. Our aim was to evaluate the prevalence and association of vasomotor and negative affect symptoms. METHODS A cross-sectional study was conducted with 89 perimenopausal women aged 45-55 years. Broad psychiatric and clinical evaluations were carried out. The primary outcome was the vasomotor symptom problem rating and the main study factor was anxiety sensitivity. Linear regression analyses were conducted to examine the associations between the study factors and the primary outcome, and a multiple regression model was created to assess which variables were independently associated with vasomotor symptom problem rating. RESULTS The prevalence of anxiety, depression, and vasomotor symptoms were 58, 62, and 73%, respectively. Negative affect symptoms were positively associated with vasomotor symptom problem rating. The association of anxiety sensitivity and vasomotor symptom problem rating remained significant after controlling for perimenopausal stage, thyrotropin, follicle-stimulating hormone levels, and psychotropic medication use (β = 0.314, p = 0.002). CONCLUSION A better understanding of the experience of vasomotor symptoms is needed, especially the role of negative affect symptoms and anxiety sensitivity. New strategies focusing on related thoughts and behaviors could improve the quality of life of perimenopausal women.

中文翻译：

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围绝经期的负面影响症状、焦虑敏感性和血管舒缩症状

目的 血管舒缩症状影响 60-80% 的绝经过渡期女性。焦虑、抑郁和焦虑敏感性可能在血管舒缩症状的痛苦经历中发挥重要作用。我们的目的是评估血管舒缩症状和负面影响症状的患病率和关联。方法 对 89 名 45-55 岁围绝经期妇女进行了横断面研究。进行了广泛的精神病学和临床评估。主要结果是血管舒缩症状问题评级，主要研究因素是焦虑敏感性。进行线性回归分析以检查研究因素与主要结果之间的关联，并创建多元回归模型以评估哪些变量与血管舒缩症状问题评级独立相关。结果 焦虑、抑郁和血管舒缩症状的患病率分别为 58%、62% 和 73%。负面情绪症状与血管舒缩症状问题评级呈正相关。在控制了围绝经期、促甲状腺激素、促卵泡激素水平和精神药物使用后，焦虑敏感性和血管舒缩症状评分之间的关​​联仍然显着（β = 0.314，p = 0.002）。结论 需要更好地了解血管舒缩症状的体验，尤其是负面情绪症状和焦虑敏感性的作用。关注相关思想和行为的新策略可以提高围绝经期妇女的生活质量。负面情绪症状与血管舒缩症状问题评级呈正相关。在控制了围绝经期、促甲状腺激素、促卵泡激素水平和精神药物使用后，焦虑敏感性和血管舒缩症状评分之间的关​​联仍然显着（β = 0.314，p = 0.002）。结论 需要更好地了解血管舒缩症状的体验，尤其是负面情绪症状和焦虑敏感性的作用。关注相关思想和行为的新策略可以提高围绝经期妇女的生活质量。负面情绪症状与血管舒缩症状问题评级呈正相关。在控制了围绝经期、促甲状腺素、促卵泡激素水平和精神药物使用后，焦虑敏感性和血管舒缩症状评分之间的关​​联仍然显着（β = 0.314，p = 0.002）。结论 需要更好地了解血管舒缩症状的体验，尤其是负面情绪症状和焦虑敏感性的作用。关注相关思想和行为的新策略可以提高围绝经期妇女的生活质量。和精神药物使用（β = 0.314，p = 0.002）。结论 需要更好地了解血管舒缩症状的体验，尤其是负面情绪症状和焦虑敏感性的作用。关注相关思想和行为的新策略可以提高围绝经期妇女的生活质量。和精神药物使用（β = 0.314，p = 0.002）。结论 需要更好地了解血管舒缩症状的体验，尤其是负面情绪症状和焦虑敏感性的作用。关注相关思想和行为的新策略可以提高围绝经期妇女的生活质量。