SummaryThis study analyzed the effects of the day of trophectoderm (TE) biopsy and blastocyst grade on clinical and neonatal outcomes. The results showed that the implantation and live birth rates of day 5 (D5) TE biopsy were significantly higher compared with those of D6 TE biopsy. The miscarriage rate of the former was lower than that of the latter, but there was no statistically significant difference. Higher quality blastocysts can achieve better implantation and live birth rates. Among good quality blastocysts, the implantation and live birth rates of D5 and D6 TE biopsy were not significantly different. Among fair quality and poor quality blastocysts, the implantation and live birth rates of D5 TE biopsy were significantly higher compared with those of D6 TE biopsy. Neither blastocyst grade nor the day of TE biopsy significantly affected the miscarriage rate. Neonatal outcomes, including newborn sex, gestational age, preterm birth, birth weight and low birth weight in the D5 and D6 TE biopsies were not significantly different. Both blastocyst grade and the day of TE biopsy must be considered at the same time when performing preimplantation genetic testing–frozen embryo transfer.

中文翻译：

---

滋养外胚层活检当天和囊胚分级对植入前基因检测-冷冻胚胎移植周期临床和新生儿结局的影响

摘要本研究分析了滋养外胚层 (TE) 活检当天和囊胚分级对临床和新生儿结局的影响。结果表明，与 D6 TE 活检相比，第 5 天（D5）TE 活检的植入率和活产率显着提高。前者流产率低于后者，但差异无统计学意义。更高质量的囊胚可以实现更好的植入率和活产率。在质量好的囊胚中，D5 和 D6 TE 活检的着床率和活产率没有显着差异。在质量一般和质量差的囊胚中，D5 TE活检的着床率和活产率明显高于D6 TE活检。囊胚等级和 TE 活检日期均未显着影响流产率。新生儿结局，包括新生儿性别、胎龄、早产、出生体重和低出生体重在 D5 和 D6 TE 活检中没有显着差异。在进行植入前基因检测——冷冻胚胎移植时，必须同时考虑囊胚等级和 TE 活检日期。