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Tuberculosis of the spine and drug resistance: a review article
Neurosurgical Review ( IF 2.8 ) Pub Date : 2021-06-26 , DOI: 10.1007/s10143-021-01595-1
Vishal Kumar 1 , Deepak Neradi 1 , Balwinder Sherry 1 , Ankit Gaurav 1 , Sarvdeep Singh Dhatt 1
Affiliation  

Pott’s spine is tuberculosis of spine caused due to hematogenous spread of mycobacterium from a primary focus. It constitutes about 50% of skeletal tuberculosis cases. Paradiscal type is the most common type of spinal tuberculosis. Untreated cases can lead to complications like a cold abscess, paraplegia, and deformity which may require surgical intervention. Rapid molecular methods have made the diagnosis of spinal tuberculosis and drug resistance faster and easier but it still remains a problem due to difficulties in sample collection and the paucibacillary nature of the Pott spine. Antitubercular drug therapy forms the mainstay of management. The emergence of MDR TB and XDR TB has posed a big challenge in the management of spinal tuberculosis. The literature regarding drug resistance in spinal tuberculosis and its management is lacking. We conducted a literature review of 29 studies and presented information on pathogenesis, diagnosis, and management of spinal tuberculosis and drug resistance. New shorter regimens for MDR and XDR TB are under trial in different parts of the world. We believe this article will provide information on spinal tuberculosis and drug resistance and help clinicians outline important research areas.



中文翻译:

脊柱结核和耐药性:一篇评论文章

Pott 的脊柱是由于分枝杆菌从主要病灶的血行播散引起的脊柱结核。它约占骨结核病例的 50%。Paradiscal type是最常见的脊柱结核类型。未经治疗的病例可能会导致并发症,如冷脓肿、截瘫和可能需要手术干预的畸形。快速分子方法使脊柱结核和耐药性的诊断更快、更容易,但由于样本采集困难和 Pott 脊柱的少杆菌性质,它仍然是一个问题。抗结核药物治疗是主要的治疗方法。耐多药结核病和广泛耐药结核病的出现给脊柱结核的管理带来了巨大挑战。缺乏关于脊柱结核耐药性及其管理的文献。我们对 29 项研究进行了文献回顾,并提供了有关脊柱结核和耐药性的发病机制、诊断和管理的信息。耐多药和广泛耐药结核病的新的较短治疗方案正在世界不同地区进行试验。我们相信本文将提供有关脊柱结核和耐药性的信息,并帮助临床医生概述重要的研究领域。

更新日期:2021-06-28
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