ABSTRACT

Background

Irritable Bowel Syndrome (IBS) and Migraine are two diseases featuring high prevalence. Previous studies have suggested a relationship between IBS and migraine, although the causal association remains unclear. The authors sought to explore the causal association between IBS and migraine, and to show the importance of migraine prevention in IBS patients.

Methods

This study conducted a Mendelian randomization analysis to explore the association of IBS with migraine. Genetic association with migraine was acquired from the UK Biobank (UKB) genetic databases (cases: 1,072; controls: 360,122). The authors performed estimation using Inverse Variance Weighting (IVW), along with Maximum Likelihood, MR-RAPS, MR-Egger, and Weighted Median for sensitivity analysis. Considering possible bias, they also conducted polymorphism, heterogeneity, and directional analysis.

Results

The IVW estimation genetically predicted the causal association between IBS and migraine (OR = 1.09, 95% CI 1.01 to 1.17, p = 0.03). Neither statistical horizontal pleiotropy (MR Egger p = 0.42; MR-PRESSO p = 0.78) nor possible heterogeneity (IVW Q = 26.15, p = 0.80) was found. Reverse causation was also not detected (p steiger<0.01).

Conclusion

Mendelian randomization analysis supported a potential causal association between IBS and migraine, providing enlightenment for disease prevention and control.

中文翻译：

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肠易激综合征和偏头痛：来自英国生物银行孟德尔随机分析的证据

摘要

背景

肠易激综合征（IBS）和偏头痛是两种高发病率的疾病。先前的研究表明 IBS 与偏头痛之间存在关系，尽管因果关系仍不清楚。作者试图探索 IBS 与偏头痛之间的因果关系，并展示预防 IBS 患者偏头痛的重要性。

方法

本研究进行了孟德尔随机化分析，以探索 IBS 与偏头痛的关系。与偏头痛的遗传关联来自英国生物银行 (UKB) 遗传数据库（病例：1,072；对照：360,122）。作者使用逆方差加权 (IVW) 以及最大似然法、MR-RAPS、MR-Egger 和加权中位数进行敏感性分析。考虑到可能存在的偏差，他们还进行了多态性、异质性和方向性分析。

结果

IVW 估计在遗传上预测了 IBS 和偏头痛之间的因果关系（OR = 1.09，95% CI 1.01 至 1.17，p = 0.03）。未发现统计水平多效性（MR Egger p = 0.42；MR-PRESSO p = 0.78）或可能的异质性（IVW Q = 26.15，p = 0.80）。也未检测到反向因果关系（p steiger<0.01）。

结论

孟德尔随机化分析支持 IBS 与偏头痛之间存在潜在的因果关系，为疾病预防和控制提供启示。