Anti-cytokine autoantibodies are self-reactive antibodies that react with cytokines and inhibit their functions. Cytokines are vital for the correct functioning of the immune system and the occurrence of these autoantibodies limiting cytokine function is enigmatic. Some healthy individuals exhibit low levels of anti-cytokine autoantibodies where they are speculated to regulate normal cytokine functions even though the experimental evidence is still lacking (1). Recent findings suggest that high levels of anti-cytokine autoantibodies targeted against type I interferons e.g., IFN-α and -ω are a significant predisposing factor for a severe COVID-19 disease and increased mortality (2). Relative contribution of anti-cytokine autoantibodies to COVID-19 morbidity and mortality of hematopoietic stem cell transplantation (HSCT) recipients is hard to approximate since there are no recent estimates how common these autoantibodies are in HSCT recipients.

中文翻译：

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抗细胞因子自身抗体在慢性移植物抗宿主病中很少见

抗细胞因子自身抗体是与细胞因子反应并抑制其功能的自身反应性抗体。细胞因子对于免疫系统的正常运作至关重要，而这些限制细胞因子功能的自身抗体的出现是个谜。一些健康个体表现出低水平的抗细胞因子自身抗体，尽管仍然缺乏实验证据，但推测它们可以调节正常的细胞因子功能 (1)。最近的研究结果表明，针对 I 型干扰素（如 IFN-α 和 -ω）的高水平抗细胞因子自身抗体是严重 COVID-19 疾病和死亡率增加的重要诱发因素 (2)。