Tissue-engineered vascular grafts are increasing in popularity in the treatment of cardiovascular disease. However, poor mechanical strength, brittle texture and other defects restrict their extensive application. In the present work, oligopeptide hybrid films were prepared by L-tyrosine-derivative oligopeptide (TEA), polyethylene glycol (PEG) and polyvinyl alcohol (PVA). The films were prepared with different PEG molecular weights and TEA contents. The chemical structures were characterized using Fourier-transform infrared spectroscopy, while the micromorphology and self-assembly behaviour were examined using scanning electron microscopy and differential scanning calorimetry. The mechanical properties of the films were investigated, and the cellular behaviour was observed using polarized optical microscopy. The experimental results indicated that the degree of microphase separation depended on the molecular weight of the PEG and TEA content. The biocompatibility of the films improved as the TEA content increased. The liquid crystalline properties of the TEA affected the cell orientation. The films are expected to be incorporated into applications in the vascular tissue engineering field.

组织工程血管移植物在心血管疾病的治疗中越来越受欢迎。但机械强度差、质地脆等缺陷限制了其广泛应用。在目前的工作中，寡肽杂化薄膜是由 L-酪氨酸衍生物寡肽 (TEA)、聚乙二醇 (PEG) 和聚乙烯醇 (PVA) 制备的。制备的薄膜具有不同的 PEG 分子量和 TEA 含量。使用傅里叶变换红外光谱表征化学结构，而使用扫描电子显微镜和差示扫描量热法检查微形态和自组装行为。研究了薄膜的机械性能，并使用偏光显微镜观察了细胞行为。实验结果表明，微相分离的程度取决于PEG的分子量和TEA的含量。薄膜的生物相容性随着 TEA 含量的增加而提高。TEA 的液晶特性影响细胞取向。预计这些薄膜将被纳入血管组织工程领域的应用中。