Bulletin of Experimental Biology and Medicine ( IF 0.7 ) Pub Date : 2021-06-26 , DOI: 10.1007/s10517-021-05205-4 K Yu Moiseev 1 , A A Spirichev 1 , L G Pankrasheva 1 , A S Martyusheva 2 , A Yu Abramova 2 , P M Maslyukov 1
Spike activity of neurons in the ventromedial nucleus (VMN) of the hypothalamus in adult (6-8 months) and aged (2 years) male rats was studied by the in vivo extracellular method using stereotaxic insertion of microelectrodes. In all animals, firing frequency of most VMN neurons increased in response to glucose administration. However, in aged rats, the mean baseline and glucose-induced spike frequencies of VMN neurons were lower than in adult animals. These results support the hypothesis that aging is associated with a decrease in the functional activity of hypothalamic neurons.
中文翻译:
衰老过程中大鼠下丘脑腹内侧核的尖峰活动
使用立体定向插入微电极的体内细胞外方法研究了成年(6-8 个月)和老年(2 岁)雄性大鼠下丘脑腹内侧核 (VMN) 中神经元的尖峰活动。在所有动物中,大多数 VMN 神经元的放电频率响应葡萄糖给药而增加。然而,在老年大鼠中,VMN 神经元的平均基线和葡萄糖诱导的尖峰频率低于成年动物。这些结果支持衰老与下丘脑神经元功能活动降低有关的假设。