We studied metastasis-promoting effect of transmembrane protease TMPRSS4 on mismatch repair (MMR)-deficient colorectal cancer liver metastasis in BALB/c nude mouse model. Histomorphological and histopathological studies showed that the number of liver metastases in the study group were significantly higher than that in the control group (p<0.05). The expression of TMPRSS4 mRNA and protein in the study group were obviously higher than in the control group (p<0.05). These findings suggest that TMPRSS4 possesses a metastasis-promoting effect and its low expression can effectively block the progression of MMR-deficient colon cancer liver metastasis.

中文翻译：

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跨膜蛋白酶 TMPRSS4 促进错配修复缺陷型结肠癌肝转移的形成和发展

我们研究了跨膜蛋白酶 TMPRSS4 对 BALB/c 裸鼠模型中错配修复 (MMR) 缺陷型结直肠癌肝转移的促进作用。组织形态学和组织病理学研究显示，研究组肝转移灶数显着高于对照组（p <0.05）。研究组TMPRSS4 mRNA和蛋白表达明显高于对照组（p <0.05）。这些发现表明，TMPRSS4具有促进转移的作用，其低表达可有效阻断MMR缺陷型结肠癌肝转移的进展。