Monoclonal antibodies (mAb) have been used as therapeutic agents for various diseases, and immunoglobulin G (IgG) is mainly used among antibody isotypes due to its structural and functional properties. So far, regardless of the purpose of the therapeutic antibody, wildtype IgG has been mainly used, but recently, the engineered antibodies with various strategies according to the role of the therapeutic antibody have been used to maximize the therapeutic efficacy. In this review paper, first, the overall structural features and functional characteristics of antibody IgG, second, the old and new techniques for antibody discovery, and finally, several antibody engineering strategies for maximizing therapeutic efficacy according to the role of a therapeutic antibody will be introduced.

单克隆抗体 (mAb) 已被用作各种疾病的治疗剂，而免疫球蛋白 G (IgG) 因其结构和功能特性而主要用于抗体同种型。迄今为止，无论治疗性抗体的目的如何，都主要使用野生型 IgG，但最近，根据治疗性抗体的作用采用各种策略的工程化抗体已被用于最大限度地提高治疗效果。在这篇综述文章中，首先，抗体 IgG 的整体结构特征和功能特征，其次，抗体发现的新旧技术，最后，根据治疗性抗体的作用最大化治疗效果的几种抗体工程策略介绍。