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Associations between remnant lipoprotein cholesterol and central systolic blood pressure in a Chinese community-based population: a cross-sectional study
Lipids in Health and Disease ( IF 4.5 ) Pub Date : 2021-06-26 , DOI: 10.1186/s12944-021-01490-0 Kaiyin Li 1 , Fangfang Fan 1 , Bo Zheng 1 , Jia Jia 1 , Bo Liu 1 , Jiahui Liu 1 , Chuyun Chen 1 , Jing Zhou 1 , Yan Zhang 1, 2 , Yong Huo 1
Lipids in Health and Disease ( IF 4.5 ) Pub Date : 2021-06-26 , DOI: 10.1186/s12944-021-01490-0 Kaiyin Li 1 , Fangfang Fan 1 , Bo Zheng 1 , Jia Jia 1 , Bo Liu 1 , Jiahui Liu 1 , Chuyun Chen 1 , Jing Zhou 1 , Yan Zhang 1, 2 , Yong Huo 1
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The lipid profile is reportedly related to peripheral blood pressure or pulse wave velocity. However, no studies have investigated the associations between lipid parameters, especially remnant lipoprotein cholesterol (RLP-C), and central systolic blood pressure (cSBP). This study used baseline data of a community-based cohort in Beijing, China. Participants who had been treated with anti-hypertensive or lipid-lowering agents were excluded. RLP-C is equal to total cholesterol (TC) minus the sum of low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C). An Omron HEM-9000AI device was used to measure non-invasive cSBP. The associations between blood lipid profile and non-invasive cSBP were evaluated using multivariable regression models. The 5173 included participants were 55.0 ± 8.5 years old; 35.7% (1845) of participants were men. Increased cSBP was significantly associated with increased TC, LDL-C, non-high-density lipoprotein cholesterol (non-HDL-C), triglyceride (TG), and RLP-C but with decreased HDL-C, even after adjusting for possible covariates. When simultaneously entering individual pairs of RLP-C and other blood lipid parameters into the multivariable regression model, RLP-C remained significantly associated with cSBP, even after adjusting for other lipids. Compared with participants who had RLP-C levels in the first quartile (Q1), cSBP for those with RLP-C in Q4 was increased to 4.57 (95% confidence interval [CI]: 3.08–6.06) mmHg after adjusting for LDL-C, 4.50 (95%CI: 2.98–6.02) mmHg after adjusting for TC, 3.91 (95%CI: 1.92–5.89) mmHg after adjusting for TG, 5.15 (95%CI: 3.67–6.63) mmHg after adjusting for HDL-C, and 4.10 (95%CI: 2.36–5.84) mmHg after adjusting for non-HDL-C. Increased blood RLP-C level was significantly associated with higher cSBP in a Chinese population, independently of other lipids, which indicates its importance in individual cardiovascular risk assessment.
更新日期：2021-06-28
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