The enantioselective palladium-catalyzed Heck arylation of olefins using arenediazonium salts is one of the last features in the evolution of a synthetic method known as the Heck-Matsuda reaction. This personal account highlights the development of the enantioselective Heck-Matsuda reaction in its initial stages, the challenges faced along the way, and the interesting findings that opened new synthetic opportunities, mainly from our laboratory, featuring the Heck-Matsuda reaction as a central player in the synthesis of bioactive and functional molecules.

中文翻译：

---

对映选择性 Heck-Matsuda 反应：从好奇心到改变游戏规则的方法论

使用芳烃重氮盐对烯烃进行对映选择性钯催化的 Heck 芳基化反应是合成方法发展中的最后一个特征之一，称为 Heck-Matsuda 反应。这篇个人报道重点介绍了对映选择性 Heck-Matsuda 反应在其初始阶段的发展、沿途面临的挑战以及主要来自我们实验室的有趣发现，这些发现开辟了新的合成机会，其中 Heck-Matsuda 反应是核心参与者在生物活性和功能分子的合成中。