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Development of a validated HPTLC-bioautographic method for evaluation of aromatase inhibitory activity of plant extracts and their constituents
Phytochemical Analysis ( IF 3.3 ) Pub Date : 2021-06-25 , DOI: 10.1002/pca.3074
Hend M Dawood 1 , Eman Shawky 1 , Hala M Hammoda 1 , Aly M Metwally 1 , Reham S Ibrahim 1
Affiliation  

Aromatase is a CYP450 enzyme that catalyses the conversion of androgens into oestrogens, where the decrease in the production of oestrogens aided by aromatase inhibitors is considered a target in post-menopausal breast cancer therapy. TLC-bioautography is a technique employed for combining chromatographic separations on TLC plates with bioassays. This is the first report to evaluate aromatase inhibitory activity using this technique.

中文翻译:

开发一种经过验证的 HPTLC 生物自显影方法,用于评估植物提取物及其成分的芳香酶抑制活性

芳香酶是一种 CYP450 酶,可催化雄激素转化为雌激素,其中芳香酶抑制剂有助于减少雌激素的产生被认为是绝经后乳腺癌治疗的目标。TLC-bioautography 是一种用于将 TLC 板上的色谱分离与生物测定相结合的技术。这是使用该技术评估芳香酶抑制活性的第一份报告。
更新日期:2021-06-25
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