The capacity to regenerate damaged or lost tissue varies widely along the animal kingdom and generally declines with aging of the organism. The gradual accumulation of senescent cells in tissues during aging has been causally involved in their reduced function at old age, and to be at the basis of age-related diseases. Recently, however, cellular senescence has been shown to play a positive role as a morphogenetic force modelling and promoting tissue development during embryogenesis, and to be responsible for tissue wound healing and repair. Work done on organismal models ranging from fish and amphibians, with extraordinary regenerative capacities, to mammals, with a more restricted regenerative potential, is shedding light on a novel and unexpected function of cellular senescence. In this review, we will analyze the senescence phenotype and how could it be contributing or restricting tissue regeneration.

再生受损或丢失组织的能力在动物界中差异很大，并且通常随着生物体的衰老而下降。衰老过程中衰老细胞在组织中的逐渐积累与它们在老年时功能下降有因果关系，并且是与年龄相关的疾病的基础。然而，最近，细胞衰老已被证明在胚胎发生过程中作为形态发生力建模和促进组织发育发挥积极作用，并负责组织伤口的愈合和修复。从具有非凡再生能力的鱼类和两栖动物到再生潜力更受限制的哺乳动物，对生物体模型所做的工作正在揭示细胞衰老的一种新颖且出乎意料的功能。在本次审查中，