Abstract

Pyrazolone and its derivatives are an crucial class of heterocyclic compounds that may be traced in in a number of well-established drugs, such as celecoxib, Lonazolac and Mepirizole (anti-inflammatory), Rimonabant (anti-obesity), CDPPB (anti-psychotic), Difenamizole (analegesic), Betazole (H₂-receptor agonist) and Fezolamine (anti-depressant). This review is an attempt to organize the reactivity of 3-amino-1-substituted-1H-pyrazol-5(4H)-ones reported in last 60 year to till date.

中文翻译：

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3-Amino-1H-pyrazol-5(4H)-one衍生物化学反应性的最新进展（第二部分）

摘要

吡唑啉酮及其衍生物是一类重要的杂环化合物，可在许多成熟的药物中进行追踪，例如塞来昔布、Lonazolac 和 Mepirizole（抗炎药）、Rimonabant（抗肥胖药）、CDPPB（抗精神病药） )、地芬那唑（镇痛药）、倍他唑（H ₂受体激动剂）和非唑胺（抗抑郁药）。这篇综述试图组织 3-amino-1-located-1 H -pyrazol-5(4 H )-ones 在过去 60 年中的反应性。