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Effective connectivity underlying reward-based executive control
Human Brain Mapping ( IF 4.8 ) Pub Date : 2021-06-26 , DOI: 10.1002/hbm.25564
Bernadette Hippmann 1 , Elinor Tzvi 2 , Martin Göttlich 1 , Ronja Weiblen 1 , Thomas F Münte 1 , Sarah Jessen 1
Affiliation  

Motivational influences on cognitive control play an important role in shaping human behavior. Cognitive facilitation through motivators such as prospective reward or punishment is thought to depend on regions from the dopaminergic mesocortical network, primarily the ventral tegmental area (VTA), inferior frontal junction (IFJ), and anterior cingulate cortex (ACC). However, how interactions between these regions relate to motivated control remains elusive. In the present functional magnetic resonance imaging study, we used dynamic causal modeling (DCM) to investigate effective connectivity between left IFJ, ACC, and VTA in a task-switching paradigm comprising three distinct motivational conditions (prospective monetary reward or punishment and a control condition). We found that while prospective punishment significantly facilitated switching between tasks on a behavioral level, interactions between IFJ, ACC, and VTA were characterized by modulations through prospective reward but not punishment. Our DCM results show that IFJ and VTA modulate ACC activity in parallel rather than by interaction to serve task demands in reward-based cognitive control. Our findings further demonstrate that prospective reward and punishment differentially affect neural control mechanisms to initiate decision-making.

中文翻译:

基于奖励的执行控制的有效连接

动机对认知控制的影响在塑造人类行为方面发挥着重要作用。通过诸如预期奖励或惩罚等激励因素的认知促进被认为取决于多巴胺能中皮层网络的区域,主要是腹侧被盖区 (VTA)、下额叶交界处 (IFJ) 和前扣带皮层 (ACC)。然而,这些区域之间的相互作用如何与动机控制相关仍然难以捉摸。在目前的功能性磁共振成像研究中,我们使用动态因果模型 (DCM) 来研究左侧 IFJ、ACC 和 VTA 在任务转换范式中的有效连接,该范式包括三种不同的动机条件(预期的金钱奖励或惩罚和控制条件) )。我们发现,虽然预期惩罚在行为层面上显着促进了任务之间的切换,但 IFJ、ACC 和 VTA 之间的相互作用的特点是通过预期奖励而不是惩罚进行调节。我们的 DCM 结果表明,IFJ 和 VTA 并行调节 ACC 活动,而不是通过交互来满足基于奖励的认知控制中的任务需求。我们的研究结果进一步表明,前瞻性奖励和惩罚会不同地影响神经控制机制以启动决策。
更新日期:2021-09-02
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