Interleukin-18, IL-18 binding protein and IL-18 receptor expression in asthma: a hypothesis showing IL-18 promotes epithelial cell differentiation,Clinical & Translational Immunology

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Interleukin-18, IL-18 binding protein and IL-18 receptor expression in asthma: a hypothesis showing IL-18 promotes epithelial cell differentiation
Clinical & Translational Immunology ( IF 5.8 ) Pub Date : 2021-06-26 , DOI: 10.1002/cti2.1301
Davinder Kaur ₁ , Latifa Chachi ₁ , Edith Gomez ₁ , Nicolas Sylvius ₂ , Christopher E Brightling ₁

Affiliation

In asthma, genome-wide association studies have shown that interleukin-18 (IL-18) receptor 1 gene (IL-18R1) and sputum IL-18 are increased during exacerbations. However, the role of the IL-18 axis in bronchial epithelial function is unclear. To investigate IL-18, IL-18 binding protein (BP) and IL-18R expression in bronchial biopsies and sputum samples from patients with asthma, and to determine its functional role using in vitro bronchial epithelial cells.

中文翻译：

白细胞介素 18、IL-18 结合蛋白和 IL-18 受体在哮喘中的表达：显示 IL-18 促进上皮细胞分化的假设

在哮喘中，全基因组关联研究表明，白细胞介素 18 (IL-18) 受体 1 基因 ( IL-18R1 ) 和痰液 IL-18 在恶化期间增加。然而，IL-18 轴在支气管上皮功能中的作用尚不清楚。研究哮喘患者支气管活检和痰标本中 IL-18、IL-18 结合蛋白 (BP) 和 IL-18R 的表达，并使用体外支气管上皮细胞确定其功能作用。

更新日期：2021-06-28

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