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Electrocatalytic cascade approach to the synthesis of dihydro-2'H,3H-spiro[1-benzofuran-2,5'-pyrimidines]
Chemistry of Heterocyclic Compounds ( IF 1.5 ) Pub Date : 2021-06-26 , DOI: 10.1007/s10593-021-02966-8
Fedor V. Ryzhkov , Michail N. Elinson , Yuliya E. Ryzhkova , Anatoly N. Vereshchagin , Artem N. Fakhrutdinov , Mikhail P. Egorov

Electrocatalytic cascade assembly of benzylidenebarbiturates and cyclohexane-1,3-diones in methanol in the presence of sodium bromide as mediator in an undivided cell results in the formation of dihydro-2'H,3H-spiro[1-benzofuran-2,5'-pyrimidines] in 72–85% yields. This electrochemical process occurs under mild conditions, and the isolation procedure after the reaction is simple. The structures of the final compounds were confirmed by 1H–13C HMBC spectroscopy.



中文翻译:

合成二氢-2'H,3H-螺[1-苯并呋喃-2,5'-嘧啶]的电催化级联方法

在溴化钠作为介质存在的情况下,亚苄基巴比妥酸盐和环己烷-1,3-二酮在甲醇中的电催化级联组装导致形成二氢-2' H ,3 H -螺[1-苯并呋喃-2,5 '-嘧啶]的产率为 72–85%。这种电化学过程发生在温和的条件下,反应后的分离过程简单。最终化合物的结构由1 H– 13 C HMBC 光谱证实。

更新日期:2021-06-28
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