Objective: To characterize behavioral and psychological symptoms of dementia (BPSD) in different dementia diagnoses: Alzheimer's disease (AD), dementia with Lewy bodies (DLB), Parkinson's disease dementia (PDD), vascular dementia (VaD), frontotemporal dementia (FTD), mixed (Mixed) and unspecified dementia. Design: Registry-based cohort study. Setting and participants: 12,137 individuals with dementia registered in two national quality registries, the Swedish registry for cognitive/dementia disorders (SveDem) and the Swedish BPSD registry, during 2010 - 2016. Methods: BPSD was assessed with the Neuropsychiatric Inventory - Nursing Home Version (NPI-NH). Multivariate logistic regression models were used to evaluate the associations between dementia diagnoses and different BPSDs in reference to a) the AD group and b) each of the other diagnostic groups. All models were adjusted for age, gender, the severity of cognitive impairment at the time of dementia diagnosis, and time between dementia diagnosis and BPSD assessment. Results: In all individuals, the three most common symptoms were aberrant motor behaviour (35,1%), agitation (32,3%), and irritability (28,7%), while euphoria (5,9%) was the least frequent. Compared to AD, we found a lower risk of delusions (in VaD, FTD, unspecified dementia), hallucinations (in VaD and FTD), agitation (in PDD, unspecified dementia), elation/euphoria (in DLB), anxiety (in PDD, unspecified dementia), disinhibition (in PDD); irritability (in DLB, PDD, unspecified dementia), aberrant motor behavior (in Mixed, VaD, unspecified dementia) and sleep and night-time behavior changes (in unspecified dementia). Higher risks of delusions (in DLB), hallucinations (in DLB, PDD), apathy (VaD, FTD), disinhibition (in FTD) and appetite and eating abnormalities (in FTD) were found compared to AD. Conclusions and Implications: In this large contemporary cohort, BPSD was common in all types of dementia, with the most common symptoms being aberrant motor behavior, agitation, and irritability. Additionally, BPSD differed depending on the dementia type.

中文翻译：

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不同痴呆症中痴呆的行为和心理症状：对 10 000 人的大规模研究。

目的：表征痴呆（BPSD）在不同痴呆诊断中的行为和心理症状：阿尔茨海默病（AD）、路易体痴呆（DLB）、帕金森病痴呆（PDD）、血管性痴呆（VaD）、额颞叶痴呆（FTD） 、混合（Mixed）和未指明的痴呆症。设计：基于注册的队列研究。设置和参与者：2010 年至 2016 年期间，在两个国家质量登记处、瑞典认知/痴呆症登记处 (SveDem) 和瑞典 BPSD 登记处登记的 12,137 名痴呆症患者。 (NPI-NH)。参考 a) AD 组和 b) 其他每个诊断组，使用多变量逻辑回归模型来评估痴呆诊断与不同 BPSD 之间的关联。所有模型都针对年龄、性别、痴呆诊断时认知障碍的严重程度以及痴呆诊断与 BPSD 评估之间的时间进行了调整。结果：在所有个体中，三个最常见的症状是异常运动行为 (35.1%)、激动 (32.3%) 和易怒 (28.7%)，而欣快感 (5.9%) 最少频繁。与 AD 相比，我们发现妄想（VaD、FTD、未指明的痴呆）、幻觉（VaD 和 FTD）、激动（PDD、未指明的痴呆）、兴高采烈/欣快（DLB）、焦虑（PDD）的风险较低，未指明的痴呆症），去抑制（在 PDD 中）；易怒（在 DLB、PDD、未指明的痴呆）、异常运动行为（在混合型、VaD、未指明的痴呆中）以及睡眠和夜间行为改变（在未指明的痴呆中）。与 AD 相比，发现妄想（DLB）、幻觉（DLB、PDD）、冷漠（VaD、FTD）、去抑制（FTD）以及食欲和饮食异常（FTD）的风险更高。结论和意义：在这个大型当代队列中，BPSD 在所有类型的痴呆症中都很常见，最常见的症状是异常的运动行为、激越和易怒。此外，BPSD 因痴呆类型而异。与 AD 相比，发现抑制（FTD）和食欲和进食异常（FTD）。结论和意义：在这个大型当代队列中，BPSD 在所有类型的痴呆症中都很常见，最常见的症状是异常的运动行为、激越和易怒。此外，BPSD 因痴呆类型而异。与 AD 相比，发现抑制（FTD）和食欲和进食异常（FTD）。结论和意义：在这个大型当代队列中，BPSD 在所有类型的痴呆症中都很常见，最常见的症状是异常的运动行为、激越和易怒。此外，BPSD 因痴呆类型而异。