Abstract Novel complexes of Ru (III), Cu (II) and Au (III) (2–4) were prepared using 6-phenyl-2-thioxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile (HL, 1) adopting either electrochemical or traditional chemical methods. The electrochemical method is preferred in the synthesis of the complexes than the chemical one because it affords pure products with higher yields in shorter reaction time. The novel thiopyridine complexes were characterized by elemental analyses, IR, 1H, 19F-NMR, TGA and DTA measurements. The antimicrobial activity evaluation revealed that the complex bearing copper metal 3 has nearly the same activity as the reference drug ciprofloxacin. Anti-inflammatory activity evaluation showed that complex 4 containing gold displayed anti-inflammatory activity higher than the reference drug celecoxib upon using carrageenan rat hind paw edema method.

中文翻译：

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新型硫吡啶配合物：设计、电化学制备和生物学评估

摘要 使用 6-苯基-2-硫代-4-(三氟甲基)-1,2-二氢吡啶-3-甲腈制备了新型 Ru (III)、Cu (II) 和 Au (III) (2-4) 配合物（ HL, 1) 采用电化学或传统化学方法。在复合物的合成中，电化学方法比化学方法更受欢迎，因为它可以在更短的反应时间内提供更高产率的纯产品。通过元素分析、IR、1H、19F-NMR、TGA 和 DTA 测量表征了新型硫吡啶配合物。抗菌活性评估表明，含铜金属 3 的配合物与参考药物环丙沙星具有几乎相同的活性。