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Substrate-controlled Diastereoselective Michael Addition of Alkylidene Malonates by Grignard Reagents
Heterocyclic Communications ( IF 2.3 ) Pub Date : 2019-11-28 , DOI: 10.1515/hc-2019-0019
Wei Zhou 1 , Qingwei Xiao 1 , Yuanyuan Chang 1 , Qifa Liu 1 , Xiaohao Zang 1 , Mengmeng Hu 1 , Xi Zeng 1 , Zhiyun Du 1 , Guifa Zhong 2
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Abstract Herein is described a diastereoselective Michael addition of Grignard reagents to α, β- unsaturated diethyl malonates incorporated with a 2-oxazolidone chiral auxiliary. The catalyst-free Michael addition proceeds with good chemical efficiency and excellent stereoselectivity; and it provides new thoughts to the asymmetric synthesis of β-substituted β3 amino acid derivatives.

中文翻译:

用格氏试剂对亚烷基丙二酸酯进行底物控制的非对映选择性迈克尔加成

摘要 本文描述了格氏试剂与 α, β-不饱和丙二酸二乙酯的非对映选择性迈克尔加成反应,并掺入了 2-恶唑烷酮手性助剂。无催化剂迈克尔加成具有良好的化学效率和优异的立体选择性;为β-取代β3氨基酸衍生物的不对称合成提供了新思路。
更新日期:2019-11-28
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