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Microwave-assisted synthesis of quinazolin-4(3H)-ones catalyzed by SbCl3
Heterocyclic Communications ( IF 2.3 ) Pub Date : 2018-12-19 , DOI: 10.1515/hc-2018-0115
Huaiyuan Kang 1 , Weili Wang 1, 2 , Qinqiang Sun 1 , Shuya Yang 1 , Juan Jin 1 , Xuewen Zhang 1 , Xiaoliang Ren 2 , Jiming Zhang 2 , Jianhua Zhou 2
Affiliation  

Abstract Antimony(III) trichloride (SbCl3) is an effective catalyst (1 mol%) for the condensation of anthranilic amide with various aldehydes or ketones to quinazolin-4(3H)-one derivatives in good to excellent yields under microwave irradiation. The process is carried out within several minutes under solvent-free conditions. This general methodology has the advantages of simplicity, mild reaction conditions and high yields of products.

中文翻译:

SbCl3 催化微波辅助合成喹唑啉-4(3H)-酮

摘要 三氯化锑 (SbCl3) 是一种有效的催化剂 (1 mol%),可用于在微波辐射下将邻氨基苯甲酰胺与各种醛或酮缩合为 quinazolin-4(3H)-one 衍生物,收率良好至极好。该过程在无溶剂条件下在几分钟内完成。这种通用方法具有简单、反应条件温和、产物收率高等优点。
更新日期:2018-12-19
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