Abstract An efficient method has been developed for the synthesis of 1,2,3 triazole-linked benzimidazole through a copper-catalyzed click reaction in ethanol at 50°C. A broad range of aromatic azides were successfully reacted with n-propynylated benzimidazole via copper-catalyzed azide-alkyne cycloaddition reactions in the absence of a ligand. This method offers many advantages including short reaction times, low cost, and simple purification procedures.

中文翻译：

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通过铜催化点击反应合成 1,2,3 三唑连接的苯并咪唑

摘要 开发了一种通过铜催化点击反应在 50°C 乙醇中合成 1,2,3 三唑连接的苯并咪唑的有效方法。在没有配体的情况下，通过铜催化的叠氮化物-炔环加成反应，多种芳香族叠氮化物与正丙炔化苯并咪唑成功反应。该方法具有许多优点，包括反应时间短、成本低和纯化程序简单。