Abstract Novel congeners of naphthalene substituted benzo[c]coumarins (2a-f) were synthesized by reaction of various 3-coumarinoyl methyl pyridinium bromide salts (1a-d) with a selected set of acetyl naphthalene in the presence of sodium acetate in refluxing glacial acetic acid. Structures of the synthesized compounds were confirmed by elemental analysis and by various spectroscopic techniques such as 1H-NMR, 13C-NMR, DEPT, and MS spectral data. Synthesised compounds were screened for antibacterial activity and cytotoxicity against different human cancer cell lines including cervix cancer (HeLa), breast cancer (MCF-7) and lung cancer (A549) using tetrazolium dye 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cell viability assay. Although with varying degrees, a significant growth inhibitory and cytotoxic effects were observed on all three cancer cell lines. Compounds 2b and 2e showed significant growth inhibitory and cytotoxicity against aforementioned cancer cell lines.

中文翻译：

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萘取代苯并[c]香豆素：抗菌活性和细胞毒性的合成、表征和评价

摘要 萘取代苯并[c]香豆素（2a-f）的新型同系物是通过各种3-香豆酰甲基溴化吡啶鎓盐（1a-d）与一组选定的乙酰萘在醋酸钠存在下在回流冰川中反应合成的。醋酸。通过元素分析和各种光谱技术如 1H-NMR、13C-NMR、DEPT 和 MS 光谱数据确认了合成化合物的结构。使用四唑鎓染料 3-(4,5-二甲基噻唑-2-yl) 筛选合成化合物对不同人类癌细胞系的抗菌活性和细胞毒性，包括宫颈癌 (HeLa)、乳腺癌 (MCF-7) 和肺癌 (A549) )-2,5-二苯基溴化四唑 (MTT) 细胞活力测定。虽然程度不同，在所有三种癌细胞系中均观察到显着的生长抑制和细胞毒性作用。化合物2b和2e对上述癌细胞系显示出显着的生长抑制和细胞毒性。