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J-shaped curve for the association between serum uric acid levels and the prevalence of blood pressure abnormalities
Hypertension Research ( IF 5.4 ) Pub Date : 2021-06-25 , DOI: 10.1038/s41440-021-00691-5
Shin Kawasoe 1 , Takuro Kubozono 1 , Satoko Ojima 1 , Takeko Kawabata 1 , Hironori Miyahara 2 , Koichi Tokushige 2 , Mitsuru Ohishi 1
Affiliation  

Low and high serum uric acid levels are associated with an increased risk of cardiovascular diseases. However, whether there is a similar association between serum uric acid levels and blood pressure abnormalities has not yet been elucidated. Data from 236,221 individuals (age, 56.0 ± 15.0 years; 107,146 men) who underwent routine health checkups were analyzed. Participants with a serum uric acid level ≤2.0 mg/dL were separated, and the remaining participants were divided into quartiles according to their serum uric acid levels. Among each group, the proportions of participants with high blood pressure (≥130/80 mmHg, and/or medication) and hypertension (≥140/90 mmHg, and/or medication), were calculated. The adjusted odds ratio of each group compared to the group with the lowest proportion of blood pressure abnormalities was calculated. The participants were divided into five groups according to their serum uric acid levels, ≤2.0, 2.1−4.0, 4.1−5.0, 5.1−6.0, and ≥6.1 mg/dL, and the prevalence of high blood pressure was 49.0, 44.6, 52.3, 58.6, and 65.3% and that of hypertension was 31.0, 27.4, 33.5, 38.7, and 43.8%, respectively. Compared to the second-lowest serum uric acid group (2.1–4.0 mg/dL), groups with higher serum uric acid levels (4.1−5.0, 5.1−6.0, and ≥6.1 mg/dL), as well as the group with the lowest serum uric acid level (≤2.0 mg/dL), showed significantly higher odds ratios for high blood pressure and hypertension. High and low serum uric acid levels were significantly associated with an increased prevalence of high blood pressure and followed a J-shaped curve.



中文翻译:

血清尿酸水平与血压异常患病率关系的J型曲线

低和高血清尿酸水平与心血管疾病风险增加有关。然而,尚未阐明血清尿酸水平与血压异常之间是否存在类似的关联。分析了接受常规健康检查的 236,221 人(年龄,56.0 ± 15.0 岁;107,146 名男性)的数据。将血清尿酸水平≤2.0 mg / dL的参与者分开,其余参与者根据其血清尿酸水平分为四分位数。在每组中,计算了患有高血压(≥130/80 mmHg,和/或药物)和高血压(≥140/90 mmHg,和/或药物)的参与者的比例。计算每组与血压异常比例最低的组相比的调整优势比。参与者根据血清尿酸水平分为五组,≤2.0、2.1-4.0、4.1-5.0、5.1-6.0和≥6.1 mg/dL,高血压患病率分别为49.0、44.6、52.3 , 58.6, 65.3%,高血压分别为 31.0, 27.4, 33.5, 38.7, 43.8%。与第二低的血清尿酸组(2.1-4.0 mg/dL)相比,血清尿酸水平较高的组(4.1-5.0、5.1-6.0 和 ≥6.1 mg/dL)以及最低血清尿酸水平(≤2.0 mg/dL),显示高血压和高血压的优势比显着更高。高和低血清尿酸水平与高血压患病率增加显着相关,并呈 J 形曲线。和≥6.1 mg/dL,高血压患病率分别为49.0、44.6、52.3、58.6和65.3%,高血压患病率分别为31.0、27.4、33.5、38.7和43.8%。与第二低的血清尿酸组(2.1-4.0 mg/dL)相比,血清尿酸水平较高的组(4.1-5.0、5.1-6.0 和 ≥6.1 mg/dL)以及最低血清尿酸水平(≤2.0 mg/dL),显示高血压和高血压的优势比显着更高。高和低血清尿酸水平与高血压患病率增加显着相关,并呈 J 形曲线。和≥6.1 mg/dL,高血压患病率分别为49.0、44.6、52.3、58.6和65.3%,高血压患病率分别为31.0、27.4、33.5、38.7和43.8%。与第二低的血清尿酸组(2.1-4.0 mg/dL)相比,血清尿酸水平较高的组(4.1-5.0、5.1-6.0 和 ≥6.1 mg/dL)以及最低血清尿酸水平(≤2.0 mg/dL),显示高血压和高血压的优势比显着更高。高和低血清尿酸水平与高血压患病率增加显着相关,并呈 J 形曲线。0 mg/dL)、血清尿酸水平较高组(4.1-5.0、5.1-6.0和≥6.1 mg/dL),以及血清尿酸水平最低组(≤2.0 mg/dL),显示高血压和高血压的优势比明显更高。高和低血清尿酸水平与高血压患病率增加显着相关,并呈 J 形曲线。0 mg/dL)、血清尿酸水平较高组(4.1-5.0、5.1-6.0和≥6.1 mg/dL),以及血清尿酸水平最低组(≤2.0 mg/dL),显示高血压和高血压的优势比明显更高。高和低血清尿酸水平与高血压患病率增加显着相关,并呈 J 形曲线。

更新日期:2021-06-25
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