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Prevalence and correlates of intentional substance use to reduce illicit opioid use in a Canadian setting
Journal of Substance Use ( IF 0.895 ) Pub Date : 2021-06-24 , DOI: 10.1080/14659891.2021.1941341
Jan Klimas 1, 2, 3 , Wing Yin Mok 1 , Stephanie Lake 1 , M Eugenia Socías 1, 2 , Kora DeBeck 1, 4 , Kanna Hayashi 1, 5 , Evan Wood 1, 2 , M-J Milloy 1, 2
Affiliation  

ABSTRACT

Background

While preliminary evidence has begun to document intentional use of one substance to reduce the use of another, the phenomenon of drug substitution among people who use illicit opioids remains understudied. Therefore, we sought to estimate the prevalence and correlates of intentional substance use to reduce illicit opioid use among persons who use drugs (PWUD).

Methods

We analyzed data from three prospective cohorts of PWUD in Vancouver, Canada, using multivariable generalized estimating equations (GEE).

Results

Between June 2012 and June 2016, 1527 participants were recruited and contributed 4991 interviews. Of those, 336 (22%) illicit opioid-using participants self-reported substitution to reduce illicit opioid use at least once during study period contributing 467 (9.4%) interviews. Among those interviews, substances substituted for opioids were alcohol (15 participants, 3.2%), stimulants (235, 50.3%), cannabis (129, 27.6%), benzodiazepines (21, 4.5%), and others (20, 4.3%). In multivariable GEE model adjusted for socio-demographic factors, reporting substitution to reduce illicit opioid use was positively associated with greater likelihood of daily cannabis use (Adjusted Odds Ratio = 1.56, 95% Confidence Interval: 1.24–1.96].

Conclusions

While daily cannabis use was associated with reporting opioid substitution attempts, additional study is needed to examine potential of cannabis/cannabinoids to reduce illicit opioid use.



中文翻译:

在加拿大环境中故意使用物质以减少阿片类药物非法使用的流行率和相关性

摘要

背景

虽然初步证据已开始记录有意使用一种物质以减少另一种物质的使用,但使用非法阿片类药物的人的药物替代现象仍未得到充分研究。因此,我们试图估计药物滥用者 (PWUD) 中有意物质使用的流行率和相关性,以减少阿片类药物的非法使用。

方法

我们使用多变量广义估计方程 (GEE) 分析了来自加拿大温哥华 PWUD 的三个前瞻性队列的数据。

结果

2012 年 6 月至 2016 年 6 月期间,招募了 1527 名参与者并提供了 4991 次访谈。其中,336 名 (22%) 非法使用阿片类药物的参与者自我报告在研究期间至少进行一次替代以减少非法阿片类药物的使用,参与了 467 次 (9.4%) 访谈。在这些采访中,替代阿片类药物的物质是酒精(15 名参与者,3.2%)、兴奋剂(235 名,50.3%)、大麻(129 名,27.6%)、苯二氮卓类药物(21 名,4.5%)和其他(20 名,4.3%) . 在针对社会人口因素调整的多变量 GEE 模型中,报告替代以减少阿片类药物的非法使用与每天使用大麻的可能性更大呈正相关(调整后的优势比 = 1.56,95% 置信区间:1.24–1.96)。

结论

虽然每天使用大麻与报告阿片类药物替代尝试有关,但还需要进行更多研究来检查大麻/大麻素减少非法阿片类药物使用的潜力。

更新日期:2021-06-24
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