Scandinavian Journal of Rheumatology ( IF 2.1 ) Pub Date : 2021-06-25 , DOI: 10.1080/03009742.2021.1926319 H Kisaoglu 1 , S Misir 2 , Y Aliyazicioglu 2 , M Kalyoncu 1
Objective
We aimed to investigate levels of interleukin-17 (IL-17) and oxidative stress in the active phase of immunoglobulin A vasculitis (IgAV) and determine whether a relationship exists among IL-17, oxidative stress, and system involvement.
Method
Patients diagnosed with IgAV, who were not given non-steroidal anti-inflammatory or steroidal drugs within a month, were enrolled. Blood samples were taken in the active and remission phases of the disease. Malondialdehyde (lipid peroxidation marker), 8-hydroxydeoxyguanosine (DNA oxidation marker), total oxidant status (TOS) and total antioxidant status (TAS) levels for oxidative stress, and IL-17 levels were measured.
Results
Forty-four patients aged 1.91–15.41 years were enrolled. IL-17 and TAS levels were significantly higher in the active phase of the disease than in the remission phase. 8-Hydroxydeoxyguanosine levels were higher in patients with gastrointestinal involvement than in patients without involvement in the active phase of the disease. A moderate positive correlation was observed between IL-17 and TAS in both active and remission phases.
Conclusion
Our results showed increased DNA oxidation in patients with gastrointestinal involvement in the active phase of IgAV, for the first time. Higher IL-17 and TAS levels in the active phase of the disease and positive correlations of TAS and IL-17 in both active and remission phases suggest that IL-17 and oxidative stress may be related.
中文翻译:
免疫球蛋白 A 血管炎患儿的白细胞介素 -17 和氧化应激
客观的
我们旨在调查免疫球蛋白 A 血管炎 (IgAV) 活动期白细胞介素 17 (IL-17) 和氧化应激的水平,并确定 IL-17、氧化应激和系统受累之间是否存在关系。
方法
被诊断为 IgAV 的患者在一个月内未接受非甾体抗炎药或甾体药物治疗。在疾病的活动期和缓解期采集血样。测量了氧化应激的丙二醛(脂质过氧化标记)、8-羟基脱氧鸟苷(DNA氧化标记)、总氧化状态(TOS)和总抗氧化状态(TAS)水平,以及IL-17水平。
结果
招募了 44 名 1.91-15.41 岁的患者。疾病活动期的 IL-17 和 TAS 水平显着高于缓解期。胃肠道受累患者的 8-羟基脱氧鸟苷水平高于疾病活动期未受累的患者。在活动期和缓解期均观察到 IL-17 和 TAS 之间存在中度正相关。
结论
我们的研究结果首次显示,胃肠道受累患者在 IgAV 活跃期的 DNA 氧化增加。疾病活动期较高的 IL-17 和 TAS 水平以及活动期和缓解期 TAS 和 IL-17 的正相关表明 IL-17 和氧化应激可能相关。