Large numbers of bioactive peptides with potential applications in protecting against human diseases have been identified from plant sources. In this review, we summarized recent progress in the research of plant-derived bioactive peptides, encompassing their production, biological effects, and mechanisms. This review focuses on antioxidant, antimicrobial, antidiabetic, and anticancer peptides, giving special attention to evidence derived from cellular and animal models. Studies investigating peptides with known sequences and well-characterized peptidic fractions or protein hydrolysates will be discussed. The use of molecular docking tools to elucidate inter-molecular interactions between bioactive peptides and target proteins is highlighted. In conclusion, the accumulating evidence from in silico, in vitro and in vivo studies to date supports the envisioned applications of plant peptides as natural antioxidants as well as health-promoting agents. Notwithstanding, much work is still required before the envisioned applications of plant peptides can be realized. To this end, future researches for addressing current gaps were proposed.

已经从植物来源中鉴定出大量在预防人类疾病方面具有潜在应用的生物活性肽。在这篇综述中，我们总结了植物源性生物活性肽研究的最新进展，包括其生产、生物学效应和机制。本综述重点关注抗氧化、抗菌、抗糖尿病和抗癌肽，特别关注来自细胞和动物模型的证据。将讨论研究具有已知序列的肽和充分表征的肽组分或蛋白质水解物的研究。强调使用分子对接工具来阐明生物活性肽和靶蛋白之间的分子间相互作用。总之，从计算机中积累的证据，迄今为止的体外和体内研究支持植物肽作为天然抗氧化剂和健康促进剂的预期应用。尽管如此，在植物肽的预期应用能够实现之前，仍然需要做很多工作。为此，提出了解决当前差距的未来研究。