Leg movement activity during sleep in multiple sclerosis with and without RLS,Journal of Clinical Sleep Medicine

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Leg movement activity during sleep in multiple sclerosis with and without RLS
Journal of Clinical Sleep Medicine ( IF 4.3 ) Pub Date : 2021-06-24 , DOI: 10.5664/jcsm.9466
Raffaele Ferri ₁ , Davide Sparasci ₂ , Anna Castelnovo _{2,

3} , Silvia Miano ₂ , Kosuke Tanioka ₄ , Naoko Tachibana ₅ , Chiara Carelli ₂ , Gianna Carla Riccitelli _{6,

7} , Giulio Disanto ₆ , Chiara Zecca _{3,

6} , Claudio Gobbi _{3,

6} , Mauro Manconi _{2,

3}

Affiliation

Study Objectives:

To carry out an analysis of leg movement activity during sleep in a polysomnography (PSG) dataset of patients with multiple sclerosis (MS), in comparison to idiopathic restless legs syndrome (iRLS) and healthy controls.

Methods:

In this cross-sectional, observational, instrumental study, fifty-seven patients (males/females: 11/46; mean age 46.2±10.2 years) with a diagnosis of MS underwent a telephone interview assessing the five standard diagnostic criteria for RLS and PSG. Sleep architecture and leg movement activity (LMA) during sleep were subsequently compared: 1) 40 MS patients without RLS (MS–RLS) vs. 28 healthy controls; 2) 17 MS patients with RLS (MS+RLS) vs. 35 patients with iRLS; 3) MS+RLS vs. MS–RLS.

Results:

MS–RLS and MS+RLS presented increased sleep latency, percentage of sleep stage N1, and reduced total sleep time compared to healthy controls and iRLS, respectively. The periodic limb movements during sleep (PLMS) index (PLMSI) was higher in MS–RLS than in healthy controls (p = 0.035) and lower in MS+RLS compared to iRLS (p = 0.024). PLMS in MS+RLS were less periodic, less often bilateral and with shorter single movements, compared to the typical PLMS in iRLS.

Conclusions:

MS is a risk factor for RLS, PLMS, and for a lower sleep quality in comparison to healthy patients. PLMS in MS+RLS are fewer and shorter if compared to iRLS. Our results suggest a dissociation between motor (PLMS) and sensory symptoms (RLS sensory component) in RLS secondary to MS, with possible treatment implications.

中文翻译：

患有或不患有不宁腿综合征的多发性硬化症患者睡眠期间的腿部运动活动

学习目标：

对多发性硬化症 (MS) 患者的多导睡眠图 (PSG) 数据集中睡眠期间的腿部运动活动进行分析，并与特发性不宁腿综合征 (iRLS) 和健康对照进行比较。

方法：

在这项横断面、观察性、工具性研究中，57 名被诊断为多发性硬化症的患者（男性/女性：11/46；平均年龄 46.2±10.2 岁）接受了电话采访，评估了 RLS 和 PSG 的五项标准诊断标准。随后比较睡眠期间的睡眠结构和腿部运动活动 (LMA)：1) 40 名无 RLS (MS-RLS) 的多发性硬化症患者与 28 名健康对照者；2) 17 名患有不宁腿综合征 (MS+RLS) 的 MS 患者与 35 名患有 iRLS 的患者；3) MS+RLS 与 MS-RLS。

结果：

与健康对照组和 iRLS 相比，MS-RLS 和 MS+RLS 分别表现出睡眠潜伏期增加、N1 阶段睡眠百分比增加以及总睡眠时间减少。MS-RLS 患者的睡眠期间周期性肢体运动 (PLMS) 指数 (PLMSI) 高于健康对照组 (p = 0.035)，而 MS+RLS 患者的睡眠期间周期性肢体运动指数 (PLMSI) 低于 iRLS (p = 0.024)。与 iRLS 中的典型 PLMS 相比，MS+RLS 中的 PLMS 周期性较少，双边较少且单次运动较短。