Tamoxifen is a selective estrogen receptor modulator widely used for treatment and prevention of estrogenic receptor-positive breast cancer. Tamoxifen is an object of growing interest in psychopharmacology as an antimanic drug, because it inhibits the protein kinase C, a molecular target of bipolar disorder. Consistently, the potential depressive effect of tamoxifen has been repeatedly reported.

中文翻译：

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给情绪障碍患者开他莫昔芬：对潜在抗躁狂与抑郁作用的系统评价。

他莫昔芬是一种选择性雌激素受体调节剂，广泛用于治疗和预防雌激素受体阳性乳腺癌。他莫昔芬作为一种抗躁狂药物在精神药理学中越来越受到关注，因为它抑制蛋白激酶 C，这是双相情感障碍的分子靶标。一致地，他莫昔芬的潜在抑制作用已被反复报道。