A facile and efficient synthetic route has been developed to substituted benzofuran-2-carboxylate 1,2,3-triazoles for the first time by reacting prop-2-yn-1-yl benzofuran-2-carboxylate with a variety of substituted aryl/benzyl azides in DMF/H₂O system employing standard click reaction. This new method has the lead of good yields, inexpensive reagents, easily available, easy work-up, mild reaction conditions, and environmentally friendly reaction conditions. All these compounds have been characterized by modern spectral techniques such as IR, ¹H NMR, and mass spectroscopy, etc. Evaluation of synthesized compounds for antimicrobial activity against specific bacterial strains like Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa along with antifungal activity against Aspergillus niger and Sclerotium rolfsii have been carried out.

中文翻译：

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一系列新型苯并呋喃-2-羧酸酯1,2,3-三唑类化合物的合成及生物学评价

通过将 2-yn-1-基苯并呋喃-2-羧酸丙酯与多种取代芳基/芳基反应，首次开发了一种简便高效的合成路线，首次合成了取代苯并呋喃-2-羧酸酯 1,2,3-三唑类化合物。苄基叠氮化物在 DMF/H ₂ O 系统中采用标准点击反应。这种新方法具有收率好、试剂便宜、易得、易处理、反应条件温和、反应条件环保等优点。所有这些化合物的特点是现代谱技术如IR，¹ H NMR，和质谱法，等等。评价合成化合物对特定细菌菌株（如金黄色葡萄球菌）的抗菌活性，已经进行了枯草芽孢杆菌、大肠杆菌、铜绿假单胞菌以及针对黑曲霉和罗夫氏菌核的抗真菌活性。