Background. Acute pancreatitis (AP) is associated with extensive fluid sequestration. The aim of this study was to determine association of fluid sequestration at 48 hours after hospital admission (FS⁴⁸) in AP patients with demographics, clinical parameters, and outcomes of AP. Methods. A prospective observational study was carried out on all adult patients with AP admitted to Tribhuvan University Teaching Hospital, Nepal, from January to September 2017. FS⁴⁸ was calculated as the difference between fluid input and output in the first 48 hours of admission. The Kruskal-Wallis test with post hoc Dunn’s test examined the difference in FS⁴⁸ between mild AP, moderately severe AP, and severe AP. Linear regression analysis was used to evaluate association between FS⁴⁸ with patients’ characteristics and outcomes of AP. Outcomes of AP assessed included pancreatic necrosis, persistent organ failure, length of stay, and in-hospital mortality. Results. Eighty patients (median age 44 years; 57% male) with a median FS⁴⁸ of 1610 mL were evaluated. The median FS⁴⁸ for mild AP, moderately severe AP, and severe AP were 1,180 mL, 2,380 mL, and 3,500 mL, respectively. There was a significant difference in pairwise comparisons between mild AP and moderately severe AP, along with mild AP and severe AP. Younger age, other etiology, and higher creatinine were independently associated with increased FS⁴⁸. Increased FS⁴⁸ was significantly associated with pancreatic necrosis, persistent organ failure, and in-hospital mortality. Conclusions. In our study population, younger age and higher creatinine were predictors of increased FS⁴⁸. Increased FS⁴⁸ was associated with poorer outcomes of AP.

中文翻译：

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与急性胰腺炎患者积液相关的因素：尼泊尔三级中心医院的前瞻性研究

背景。急性胰腺炎 (AP) 与大量积液有关。本研究的目的是确定AP 患者入院后 48 小时 (FS ⁴⁸ )的液体隔离与人口统计学、临床参数和 AP 结局的关联。方法。对 2017 年 1 月至 9 月尼泊尔特里布万大学教学医院收治的所有成年 AP 患者进行了一项前瞻性观察研究。 FS ⁴⁸计算为入院前 48 小时的液体输入和输出之间的差异。Kruskal-Wallis 检验和事后 Dunn 检验检验了 FS ⁴⁸的差异介于轻度 AP、中重度 AP 和重度 AP 之间。线性回归分析用于评估 FS ⁴⁸与患者特征和 AP 结局之间的关联。评估的 AP 结局包括胰腺坏死、持续性器官衰竭、住院时间和住院死亡率。结果。评估了80 名患者（中位年龄 44 岁；57% 为男性），中位 FS ⁴⁸为 1610 mL。中位数 FS ⁴⁸轻度 AP、中重度 AP 和重度 AP 分别为 1,180 mL、2,380 mL 和 3,500 mL。轻度 AP 和中度重度 AP 以及轻度 AP 和重度 AP 之间的成对比较存在显着差异。较年轻的年龄、其他病因和较高的肌酐与 FS 的增加独立相关⁴⁸。FS ⁴⁸增加与胰腺坏死、持续性器官衰竭和住院死亡率显着相关。结论。在我们的研究人群中，年龄较小和肌酐较高是 FS 增加的预测因素⁴⁸。FS ^{48 的}增加与 AP 较差的结果相关。