“Superbugs”, multidrug-resistant microorganisms, have become a significant threat to the global healthcare sector over the past few decades. Among other diseases, invasive fungal infections caused by the Candida species are the most common cause of nosocomial infections with antifungal resistance. This work has employed a facile aqueous phase process to synthesize a stable, cationic silver nanoparticle using polyethyleneimine (PEI) as both a reducing and stabilizing agent. We determined that the polymer ratio plays a vital role in particle size and charge. As a result, the efficacy of antimicrobial activity was inversely proportional to the particle size from the disc diffusion and microdilution method. Furthermore, the smallest nanoparticles were shown to inhibit biofilm formation of Candida on silicon catheters and proved to be an efficient and potential anticandidal agent against the standard and clinical isolates of Candida. Therefore, the current investigation paves a new avenue for the green fabrication of nano‑silver based anticandidal agents.

“超级细菌”，即多重耐药微生物，在过去几十年中已成为全球医疗保健行业的重大威胁。在其他疾病中，念珠菌属引起的侵袭性真菌感染是抗真菌耐药性医院感染的最常见原因。这项工作采用了一种简便的水相工艺，使用聚乙烯亚胺 (PEI) 作为还原剂和稳定剂来合成稳定的阳离子银纳米颗粒。我们确定聚合物比例对粒度和电荷起着至关重要的作用。因此，抗菌活性的功效与来自圆盘扩散和微量稀释方法的粒径成反比。此外，最小的纳米颗粒被证明可以抑制生物膜的形成念珠菌上硅导管和被证明是针对标准和临床分离物的有效的和潜在的抗念珠菌剂念珠菌。因此，目前的研究为纳米银基抗念珠菌剂的绿色制造铺平了新的途径。