Incidence rates of hematological malignancies have been constantly increasing over the past 40 years. In parallel, an expanding use of agricultural pesticides has been observed. Only a limited number of studies investigated the link between hematological malignancies risk and passive environmental residential exposure to agricultural pesticides in the general population. The purpose of our review was to summarize the current state of knowledge on that question. A systematic literature search was conducted using PubMed and Scopus databases. We built a scoring scale to appraise relevance of each selected articles. We included 23 publications: 13 ecological studies, 9 case-control studies and a cohort study. Positive associations were reported between hematological malignancies and individual pesticides, pesticide groups, all pesticides without distinction, or some crop types. Relevance score was highly various across studies regardless of their design. Children studies were the majority and had overall higher relevance scores. The effect of passive environmental residential exposure to agricultural pesticides on hematological malignancies risk is suggested by the literature. The main limitation of the literature available is the high heterogeneity across studies, especially in terms of exposure assessment approach. Further studies with high methodological relevance should be conducted.

在过去的 40 年中，血液系统恶性肿瘤的发病率一直在不断增加。与此同时，已经观察到农业杀虫剂的使用扩大。只有少数研究调查了一般人群中血液恶性肿瘤风险与被动环境居民接触农用杀虫剂之间的联系。我们审查的目的是总结有关该问题的当前知识状态。使用 PubMed 和 Scopus 数据库进行了系统的文献检索。我们建立了一个评分量表来评估每篇所选文章的相关性。我们纳入了 23 篇出版物：13 项生态研究、9 项病例对照研究和一项队列研究。据报道，血液系统恶性肿瘤与单个农药、农药组、所有农药无差别，或某些作物类型。无论研究设计如何，相关性评分在不同研究中都存在很大差异。儿童研究占大多数，总体相关性得分较高。文献表明被动环境居民接触农用杀虫剂对血液系统恶性肿瘤风险的影响。现有文献的主要限制是研究之间的高度异质性，特别是在暴露评估方法方面。应进行具有高度方法学相关性的进一步研究。文献表明被动环境居民接触农用杀虫剂对血液系统恶性肿瘤风险的影响。现有文献的主要限制是研究之间的高度异质性，特别是在暴露评估方法方面。应进行具有高度方法学相关性的进一步研究。文献表明被动环境居民接触农用杀虫剂对血液系统恶性肿瘤风险的影响。现有文献的主要限制是研究之间的高度异质性，特别是在暴露评估方法方面。应进行具有高度方法学相关性的进一步研究。