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The molecular mechanisms supporting the homeostasis and activation of dendritic epidermal T cell and its role in promoting wound healing
Burns & Trauma ( IF 5.3 ) Pub Date : 2021-05-31 , DOI: 10.1093/burnst/tkab009
Cheng Chen 1 , Ziyu Meng 2 , He Ren 3 , Na Zhao 3 , Ruoyu Shang 1 , Weifeng He 1 , Jianlei Hao 4, 5
Affiliation  

The epidermis is the outermost layer of skin and the first barrier against invasion. Dendritic epidermal T cells (DETCs) are a subset of γδ T cells and an important component of the epidermal immune microenvironment. DETCs are involved in skin wound healing, malignancy and autoimmune diseases. DETCs secrete insulin-like growth factor-1 and keratinocyte growth factor for skin homeostasis and re-epithelization and release inflammatory factors to adjust the inflammatory microenvironment of wound healing. Therefore, an understanding of their development, activation and correlative signalling pathways is indispensable for the regulation of DETCs to accelerate wound healing. Our review focuses on the above-mentioned molecular mechanisms to provide a general research framework to regulate and control the function of DETCs.

中文翻译:

支持树突状表皮T细胞稳态和活化的分子机制及其促进伤口愈合的作用

表皮是皮肤的最外层,是抵御入侵的第一道屏障。树突状表皮 T 细胞 (DETC) 是 γδ T 细胞的一个子集,是表皮免疫微环境的重要组成部分。DETCs 参与皮肤伤口愈合、恶性肿瘤和自身免疫性疾病。DETCs分泌胰岛素样生长因子-1和角质形成细胞生长因子用于皮肤稳态和再上皮化,并释放炎性因子以调节伤口愈合的炎性微环境。因此,了解它们的发育、激活和相关信号通路对于调节 DETC 加速伤口愈合是必不可少的。我们的综述侧重于上述分子机制,以提供一个通用的研究框架来调节和控制 DETCs 的功能。
更新日期:2021-05-31
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