Epidermophyton floccosum is one of the most common agents of human superficial fungal infections, compared with genus Trichophyton and Microsporum, it possesses uniqueness in ecology traits and rarely causing hair infections. E. floccosum is so far the only representative species of genera Epidermophyton, and it is known as anthropophilic dermatophytes. To further reveal the genome sequences and clues of virulence factors, thus in this study, we sequenced the genome of E. floccosum (CGMCC (F) E1d), and performed comparative genomic analysis with other dermatophytes. It is revealed that E. floccosum owns the largest genome size and similar GC content compared with other dermatophytes. A total of 7565 genes are predicted. By comparing with the closest species N. gypseum, our study reveals that number and structure of adhesion factors, secreted proteases and LysM domain might contribute to the pathogenic and ecological traits of E. floccosum. Mating genes is also detected in genome data. Furthermore, we performed AFLP analysis trying to discuss intraspecific differences of E. floccosum, but no significant relationship is found between genotype and geographical distribution. Upon above, our study provides a deeper understanding and strong foundation for future researches about E. floccosum.

絮状表皮癣菌是人类浅表真菌感染最常见的病原体之一，与毛癣菌属和小孢子菌属相比，它具有独特的生态特性，很少引起毛发感染。E. floccosum是迄今为止表皮癣菌属的唯一代表性物种，被称为嗜人性皮肤癣菌。为了进一步揭示毒力因子的基因组序列和线索，本研究对絮状大肠杆菌（CGMCC (F) E1d）的基因组进行测序，并与其他皮肤癣菌进行基因组比较分析。据透露，E. floccosum与其他皮肤癣菌相比，具有最大的基因组大小和相似的 GC 含量。总共预测了7565个基因。通过与最接近的物种N. gypseum进行比较，我们的研究表明粘附因子、分泌的蛋白酶和 LysM 结构域的数量和结构可能有助于E. floccosum的致病和生态特性。在基因组数据中也检测到交配基因。此外，我们进行了 AFLP 分析，试图讨论E. floccosum 的种内差异，但未发现基因型与地理分布之间存在显着关系。综上所述，我们的研究为今后对絮状大肠杆菌的研究提供了更深入的认识和坚实的基础。