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Chemical-mediated translocation in protocell-based microactuators
Nature Chemistry ( IF 21.8 ) Pub Date : 2021-06-24 , DOI: 10.1038/s41557-021-00728-9
Ning Gao 1, 2 , Mei Li 1, 3 , Liangfei Tian 1, 4 , Avinash J Patil 1 , B V V S Pavan Kumar 1, 5 , Stephen Mann 1, 2, 3
Affiliation  

Artificial cell-like communities participate in diverse modes of chemical interaction but exhibit minimal interfacing with their local environment. Here we develop an interactive microsystem based on the immobilization of a population of enzyme-active semipermeable proteinosomes within a helical hydrogel filament to implement signal-induced movement. We attach large single-polynucleotide/peptide microcapsules at one or both ends of the helical protocell filament to produce free-standing soft microactuators that sense and process chemical signals to perform mechanical work. Different modes of translocation are achieved by synergistic or antagonistic enzyme reactions located within the helical connector or inside the attached microcapsule loads. Mounting the microactuators on a ratchet-like surface produces a directional push–pull movement. Our methodology opens up a route to protocell-based chemical systems capable of utilizing mechanical work and provides a step towards the engineering of soft microscale objects with increased levels of operational autonomy.



中文翻译:

基于原始细胞的微致动器中的化学介导易位

人工细胞样群落参与多种化学相互作用模式,但与当地环境的相互作用极少。在这里,我们开发了一个交互式微系统,该系统基于将一组酶活性半透性蛋白体固定在螺旋水凝胶细丝内,以实现信号诱导的运动。我们将大型单多核苷酸/肽微胶囊附着在螺旋原细胞丝的一端或两端,以产生独立的软微致动器,该微致动器可感知和处理化学信号以执行机械工作。通过位于螺旋连接器内或附着的微囊负载内的协同或拮抗酶反应实现不同的易位模式。将微执行器安装在棘轮状表面上会产生定向推拉运动。

更新日期:2021-06-24
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