GREB1L is a protein-coding gene that is an important paralog of GREB1. However, its effects in lung adenocarcinoma (LUAD) have not been determined. Thus, we evaluated the prognostic value of GREB1L in LUAD using bioinformatics approaches. In particular, we evaluated the relationship between GREB1L and LUAD using a wide range of databases and analysis tools, including TCGA, GEO, HPA, TIMER, cBioPortal, and MethSurv. Compared with its expression in normal lung tissues, GREB1L expression was significantly increased in LUAD tissues. A univariate Cox analysis showed that high GREB1L expression levels were correlated with a poor OS in LUAD. Additionally, GREB1L expression was independently associated with OS through a multivariate Cox analysis. GSEA analysis revealed enrichment in cell cycle, immune regulation, and methylation. Moreover, high GREB1L expression was associated with poor survival. We also found that the methylation and genetic alteration level was associated with prognosis in patients with LUAD. Finally, an analysis of immune infiltration showed that GREB1L is correlated with immune cell infiltration, PD-1, and PD-L1. In summary, these results indicate that GREB1L is a potential molecular marker for poor prognosis in LUAD and provide additional insight for the development of therapies and prognostic markers.

GREB1L 是一种蛋白质编码基因，是 GREB1 的重要旁系同源基因。然而，其对肺腺癌 (LUAD) 的影响尚未确定。因此，我们使用生物信息学方法评估了 GREB1L 在 LUAD 中的预后价值。特别是，我们使用广泛的数据库和分析工具评估了 GREB1L 和 LUAD 之间的关系，包括 TCGA、GEO、HPA、TIMER、cBioPortal 和 MethSurv。与其在正常肺组织中的表达相比，GREB1L在LUAD组织中的表达显着增加。单变量 Cox 分析表明，高 GREB1L 表达水平与 LUAD 中较差的 OS 相关。此外，通过多变量 Cox 分析，GREB1L 表达与 OS 独立相关。GSEA 分析揭示了细胞周期、免疫调节和甲基化的富集。而且，高 GREB1L 表达与较差的存活率相关。我们还发现甲基化和基因改变水平与 LUAD 患者的预后相关。最后，免疫浸润分析表明 GREB1L 与免疫细胞浸润、PD-1 和 PD-L1 相关。总之，这些结果表明 GREB1L 是 LUAD 预后不良的潜在分子标志物，并为治疗和预后标志物的开发提供了额外的见解。