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Association of hepatic steatosis derived from ultrasound and quantitative MRI with prediabetes in the general population
Scientific Reports ( IF 4.6 ) Pub Date : 2021-06-24 , DOI: 10.1038/s41598-021-92681-3
Muhammad Naeem 1, 2 , Robin Bülow 3, 4 , Sabine Schipf 1 , Nicole Werner 1 , Marcus Dörr 4, 5 , Markus M Lerch 6 , Jens-Peter Kühn 7 , Wolfgang Rathmann 8, 9 , Matthias Nauck 10 , Marcello Ricardo Paulista Markus 4, 5 , Till Ittermann 1 , Henry Völzke 1, 4, 8
Affiliation  

The aim of our study was to investigate the association of hepatic steatosis derived from quantitative ultrasound and magnetic resonance imaging (MRI) with prediabetes in a large population-based study conducted in Northeast Germany. Hepatic steatosis was assessed through transabdominal ultrasound and quantitative MRI. For analysis we included 1622 subjects with MRI who participated in an oral glucose tolerance test and reported no known type 2 diabetes mellitus (T2DM). We classified participants as proposed by the American Diabetes Association: isolated impaired fasting glucose (i-IFG), isolated impaired glucose tolerance (i-IGT), combined IFG and IGT (IFG + IGT), and undiagnosed T2DM. Regression models were adjusted for age, sex body mass index and alcohol consumption. We observed positive associations of hepatic steatosis with glycated hemoglobin, fasting glucose and insulin, 2-h glucose and insulin, as well as homeostasis model assessment-insulin resistance index. Similarly, individuals having hepatic steatosis as defined by MRI had a higher relative risk ratio (RR) to be in the prediabetes groups i-IFG (RR = 1.6; 95% confidence interval (CI) 1.2; 2.2), i-IGT (RR = 3.3, 95% CI 2.0; 5.6) and IFG + IGT (RR = 2.5, 95% CI 1.6; 3.9) or to have undiagnosed T2DM (RR = 4.8, 95% CI 2.6; 9.0). All associations were attenuated when defining hepatic steatosis by ultrasound. Hepatic steatosis is associated with prediabetes and undiagnosed T2DM in the general population. Quantitative liver MRI revealed stronger associations with prediabetes and undiagnosed T2DM compared to ultrasound, which indicates the higher sensitivity and specificity of MRI to determine hepatic steatosis.



中文翻译:

来自超声和定量 MRI 的肝脂肪变性与普通人群糖尿病前期的相关性

我们研究的目的是在德国东北部进行的一项基于人群的大型研究中,调查定量超声和磁共振成像 (MRI) 得出的肝脂肪变性与糖尿病前期的关联。通过经腹超声和定量 MRI 评估肝脏脂肪变性。为了进行分析,我们纳入了 1622 名 MRI 受试者,他们参加了口服葡萄糖耐量试验并且报告没有已知的 2 型糖尿病 (T2DM)。我们按照美国糖尿病协会的建议将参与者分类:孤立性空腹血糖受损 (i-IFG)、孤立性糖耐量减低 (i-IGT)、IFG 和 IGT 联合 (IFG + IGT) 以及未确诊的 T2DM。回归模型根据年龄、性别体重指数和饮酒量进行了调整。我们观察到肝脂肪变性与糖化血红蛋白、空腹血糖和胰岛素、2 小时血糖和胰岛素以及稳态模型评估 - 胰岛素抵抗指数呈正相关。类似地,具有 MRI 定义的肝脂肪变性的个体在糖尿病前期组 i-IFG(RR = 1.6;95% 置信区间 (CI) 1.2;2.2)、i-IGT(RR = 3.3, 95% CI 2.0; 5.6) 和 IFG + IGT (RR = 2.5, 95% CI 1.6; 3.9) 或未确诊的 T2DM (RR = 4.8, 95% CI 2.6; 9.0)。当通过超声定义肝脂肪变性时,所有关联都减弱了。在一般人群中,肝脂肪变性与前驱糖尿病和未确诊的 T2DM 相关。与超声相比,定量肝脏 MRI 显示与前驱糖尿病和未确诊的 T2DM 有更强的关联,

更新日期:2021-06-24
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