Glioma stem cells (GSCs) live in a continuous process of stemness reprogramming to achieve specific cell commitment within the so-called GSC niches, specifically located in periarteriolar regions. In this review, we analyze the expression levels, cellular and subcellular location, and role of three scaffold proteins (IQGAP1, FKBP51, and AmotL2) in GSC niches. Scaffold proteins contribute to cell differentiation, migration, and angiogenesis in glioblastoma. It could be of diagnostic interest for establishing stages, for therapeutic targets, and for improving glioblastoma prognosis, which is still at the experimental level.

中文翻译：

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胶质母细胞瘤干细胞壁中的 AmotL2、IQGAP1 和 FKBP51 支架蛋白

胶质瘤干细胞 (GSC) 存在于干细胞重编程的连续过程中，以在所谓的 GSC 壁龛内实现特定的细胞定型，特别是位于动脉周围区域。在这篇综述中，我们分析了三种支架蛋白（IQGAP1、FKBP51 和 AmotL2）在 GSC 壁龛中的表达水平、细胞和亚细胞定位以及作用。支架蛋白有助于胶质母细胞瘤中的细胞分化、迁移和血管生成。它可能对建立阶段、治疗目标和改善胶质母细胞瘤预后具有诊断意义，这仍处于实验水平。