Lipid-based signalling modulates several cellular processes and intercellular communication during wound healing and tissue regeneration. Bioactive lipids include but are not limited to the diverse group of eicosanoids, phospholipids, and extracellular vesicles and mediate the attraction of immune cells, initiation of inflammatory responses, and their resolution. In aged individuals, wound healing and tissue regeneration are greatly impaired, resulting in a delayed healing process and non-healing wounds. Senescent cells accumulate with age in vivo, preferably at sites implicated in age-associated pathologies and their elimination was shown to alleviate many age-associated diseases and disorders. In contrast to these findings, the transient presence of senescent cells in the process of wound healing exerts beneficial effects and limits fibrosis. Hence, clearance of senescent cells during wound healing was repeatedly shown to delay wound closure in vivo. Recent findings established a dysregulated synthesis of eicosanoids, phospholipids and extracellular vesicles as part of the senescent phenotype. This intriguing connection between cellular senescence, lipid-based signalling, and the process of wound healing and tissue regeneration prompts us to compile the current knowledge in this review and propose future directions for investigation.

基于脂质的信号在伤口愈合和组织再生过程中调节多种细胞过程和细胞间通讯。生物活性脂质包括但不限于不同组的类花生酸、磷脂和细胞外囊泡，并介导免疫细胞的吸引、炎症反应的启动及其消退。在老年人中，伤口愈合和组织再生严重受损，导致愈合过程延迟和伤口不愈合。衰老细胞在体内随着年龄的增长而积累，最好是在与年龄相关的病理学有关的部位，并且它们的消除被证明可以减轻许多与年龄相关的疾病和障碍。与这些发现相反，衰老细胞在伤口愈合过程中的短暂存在发挥了有益作用并限制了纤维化。因此，在伤口愈合过程中清除衰老细胞被反复证明会延迟体内伤口闭合。最近的研究结果表明，类花生酸、磷脂和细胞外囊泡的合成失调是衰老表型的一部分。细胞衰老、基于脂质的信号传导以及伤口愈合和组织再生过程之间的这种有趣联系促使我们在这篇综述中汇总当前的知识并提出未来的研究方向。