Arynes, strained cyclic alkynes, and strained cyclic allenes were validated as plausible intermediates in the 1950s and 1960s. Despite initially being considered mere scientific curiosities, these transient and highly reactive species have now become valuable synthetic building blocks. This Perspective highlights recent advances in the field that have allowed access to structural and stereochemical complexity, including recent breakthroughs in asymmetric catalysis.

中文翻译：

---

利用转瞬即逝的紧张中间体来访问复杂的支架

芳炔、应变环状炔烃和应变环状丙二烯在 1950 年代和 1960 年代被证实为合理的中间体。尽管最初被认为仅仅是科学上的好奇心，但这些瞬态和高反应性的物种现在已成为有价值的合成构件。该观点强调了该领域的最新进展，这些进展允许获得结构和立体化学的复杂性，包括最近在不对称催化方面的突破。